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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status

Fig. 2

Summary copy number plots derived from DNA methylation data, showing the proportion of tumor samples with gains (above the baseline) or losses (below the baseline) at the respective position. a Summary copy number plot of hormone receptor positive (n = 282) and triple negative samples (TNBC; n = 52) from The Cancer Genome Atlas (TCGA). b Summary copy number plot comparing genome wide copy number profiles of samples with low hormone receptor expression that clustered with hormone receptor positive (LowHR HRpos-like; n = 13) or triple negative breast cancers (LowHR TNBC-like; n = 10) in unsupervised hierarchical cluster analysis. The focal spike at chromosome 17q in the LowHR HRpos-like subgroup represents the gene locus of ERBB2

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Clinical Epigenetics

ISSN: 1868-7083

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