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Table 3 The multiplication interactive associations of progesterone and methylation level of SOCS3 (Chr17:76356190 or Chr17:76356199) on T2DM

From: Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study

Variables

ORs (95% CIs)

P-interaction

Progesterone

M_190 or M_199

Men

   

Progesterone

2.77 (1.79, 4.29)*

  

M_190

 

0.58 (0.39, 0.86)*

 

M_199

 

0.27 (0.14, 0.51)*

 

Progesterone + M_190

2.83 (1.82, 4.40)*

0.55 (0.36, 0.84)*

 

Progesterone + M_199

3.00 (1.91, 4.71)*

0.24 (0.12, 0.46)*

 

Progesterone + M_190 + Progesterone × M_190

1.98 (0.82, 4.79)*

0.37 (0.14, 0.99)*

0.367

Progesterone + M_199 + Progesterone × M_199

2.28 (0.70, 7.44)

0.17 (0.04, 0.80)

0.625

Postmenopausal women

   

Progesterone

1.85 (1.26, 2.72)*

  

M_190

 

0.43 (0.29, 0.65)*

 

M_199

 

0.53 (0.28, 0.99)*

 

Progesterone + M_190

1.87 (1.27, 2.77)*

0.41 (0.26, 0.62)*

 

Progesterone + M_199

1.90 (1.29, 2.81)*

0.47 (0.25, 0.91)*

 

Progesterone + M_190 + Progesterone × M_190

3.46 (1.41, 8.51)*

0.74 (0.31, 1.77)

0.129

Progesterone + M_199 + Progesterone × M_199

6.35 (1.95, 20.67)*

1.85 (0.47, 7.24)

0.029

  1. Adjusted for age, smoking status, drinking status, physical activity, family history of T2DM, BMI, PP, TC, and TG
  2. CI, confidence interval; OR, odds ratio; M_190, methylation of Chr17:76,356,190; M_199, methylation of Chr17:76,356,199. *P < 0.05