Table 2 Restored DMRs in vitamin C supplemented smokers versus placebo
Chr | Start | End | Nearest genes | n CpGs | Šidák adjusted p value | Genomic Region | mean ∆β VP | mean ∆β PN | % Restored |
|---|---|---|---|---|---|---|---|---|---|
5 | 72596701 | 72597716 | TMEM174/FOXD1 | 7 | 2.52E−07 | IGR-shore | 4.8% | − 2.3% | 207% |
17 | 64225346 | 64226104 | APOH | 5 | 8.85E−06 | Body-opensea | 0.1% | − 0.2% | 33% |
17 | 64652223 | 64652404 | PRKCA | 2 | 2.63E−05 | Body-opensea | − 0.1% | 0.8% | 7% |
7 | 150951482 | 150952100 | SMARCD3 | 7 | 9.14E−05 | Body-shelf | − 0.5% | 0.3% | 143% |
10 | 743286 | 743974 | DIP2C | 6 | 1.65E−04 | IGR-island | − 0.4% | 0.1% | 654% |
14 | 64760831 | 64761520 | ESR2 | 8 | 2.16E−04 | 1stExon-shore | 0.1% | − 0.9% | 8% |
14 | 100203730 | 100204259 | EML1 | 8 | 2.45E−04 | IGR-shore | 0.7% | − 1.7% | 43% |
17 | 81015941 | 81016295 | B3GNTL1 | 4 | 2.70E−04 | IGR-shore | − 0.9% | 0.2% | 403% |
11 | 31832710 | 31833310 | PAX6 | 13 | 4.10E−04 | 5'UTR-island | − 5.7% | 1.4% | 419% |
7 | 149472934 | 149473464 | SSPO | 4 | 7.88E−04 | TSS200-shore | − 0.3% | 0.2% | 167% |
9 | 140193776 | 140193935 | NRARP | 3 | 8.37E−04 | IGR-shore | − 1.9% | 1.6% | 117% |
4 | 42399115 | 42400465 | SHISA3 | 9 | 9.46E−04 | TSS1500-shore | − 0.6% | 1.3% | 42% |
5 | 176810555 | 176811258 | SLC34A1 | 7 | 1.36E−03 | TSS1500-opensea | 0.2% | − 0.2% | 114% |
18 | 12727080 | 12727198 | PSMG2 | 2 | 4.26E−03 | IGR-opensea | 0.0% | 0.3% | 2% |
17 | 64636808 | 64636928 | PRKCA | 2 | 5.36E−03 | Body-opensea | 0.6% | − 0.3% | 185% |
2 | 103041487 | 103041922 | IL18RAP | 2 | 6.31E−03 | Body-opensea | 0.6% | − 1.2% | 54% |
17 | 64499496 | 64499742 | PRKCA | 2 | 7.98E−03 | Body-opensea | − 0.3% | 0.3% | 102% |
10 | 740024 | 740191 | DIP2C | 2 | 8.97E−03 | IGR-shelf | − 1.0% | 0.4% | 240% |
7 | 150896413 | 150896490 | ABCF2 | 3 | 3.07E−02 | IGR-opensea | − 0.8% | 0.4% | 195% |