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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker

Fig. 2

5hmC levels in relation to transcription start sites. Median 5hmC and 5mC within ± 10 kilo base pairs from the nearest gene transcription start site (TSS) for both tumors (n = 27) and non-tumors (n = 3). We observed that there were minimal differences between tumors and non-tumors near the transcription start sites and both cytosine modifications were depleted. However, within less than 1000 base pairs of the TSS, tumors were hypohydroxymethylated and hypermethylated as compared to controls

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Clinical Epigenetics

ISSN: 1868-7083

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