Fig. 3

Dynamic methylation patterns observed during PCa therapy administration and their biological relevance. Stacked bar graphs for A taxanes and B AR inhibitors, indicate the proportion of the top 5% most variable probes (located in 5′ regulatory regions) with an absolute methylation change ≥ 0.1 between the time-points before and after therapy administration. Probes are classified as hyper- or hypomethylated according to whether the change resulted in a gain or loss of methylation, respectively. Subjects for whom these two therapies were administered simultaneously (*) are indicated. Gene ontology (GO) analysis of probes with methylation changes that were consistent with administration of C taxanes and D AR inhibitors. Total number of significant GO terms, for each subject and each dataset (hyper and hypo) is indicated in the right and left edges of the graph. Significance threshold was set at FDR p value < 0.05