Fig. 4
DYT28 is characterized by a hypermethylation pattern on specific gene regions. Histograms illustrate the non-random gene region distribution for episignature’s probes (A), and DMRs (B) in DYT28 patients. Fisher’s exact test was used to report the statistical significance of the enrichment/depletion with respect to genomic background (EPIC array). TSS200, transcription start sites 1–200; TSS, transcription start sites 201–1500; IGR, intergenic regions. A Percentage and statistical significance of feature enrichment for DYT28 episignature: *P < 0.01; **P < 10−3 ***P < 10−6; B Percentage and statistical significance of feature enrichment for DMRs in DYT28 patients: *P < 0.05; **P < 0.01 ***P < 0.001