Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory

Salles, Juliette; Eddiry, Sanaa; Lacassagne, Emmanuelle; Laurier, Virginie; Molinas, Catherine; Bieth, Éric; Franchitto, Nicolas; Salles, 
Jean-Pierre; Tauber, Maithé

doi:10.1186/s13148-021-01143-0

Table 2 Description of the top 100 of the gene with the higher methylation difference (50 hypermethylated genes and 50 hypomethylated genes)

From: Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory

	Genes	Methylation difference (%)	p value
Top 50 of the hypomethylated genes	GGT6	− 100	0.000514363
	GRK5	− 100	0.000,635,702
	KCNJ15	− 100	0.000,170,544
	LOC101927824	− 100	5.8E−23
	MAP1B	− 100	0.000,405,688
	PHRF1	− 100	0.000,635,702
	RAB3GAP1	− 100	0.000,621,357
	ZNF592	− 100	0.000,405,688
	ITGA9− AS1	− 97,44,493,917	0.0,000,013
	LYST	− 97,44,493,917	0.0,000,013
	APC2	− 97,3,698,163	0.00,109,708
	PSMD12	− 97,3,698,163	0.00,109,708
	LOC728743	− 96,97,178,877	0.000,564,938
	TTC39B	− 96,97,178,877	0.000,564,938
	CXADR	− 96,68,781,868	0.0,000,176
	TDRD10	− 96,00,217,622	0.0,000,356
	CCER2	− 95,55,845,589	0.00,000,562
	TBC1D22A	− 95,55,845,589	0.00,000,562
	ZNF510	− 92,27,324,274	0.000,437,373
	ABCG4	− 92,05,494,615	2.35883E−09
	GJC1	− 92,05,494,615	2.35883E−09
	CYP27A1	− 91,74,804,204	5.85E−08
	WDR78	− 91,36,703,468	0.000,000,003
	LOC102723665	− 90,51,175,406	0.000,568,276
	SH3D19	− 90,51,175,406	0.000,568,276
	ACOT9	− 89,67,481,584	2.12E−49
	LINC00476	− 89,67,481,584	2.12E−49
	CACFD1	− 87,25,081,098	0.00,000,197
	MTCP1	− 87,25,081,098	0.00,000,197
	GOLGA7B	− 87,13,880,766	2.60667E−05
	GSDMD	− 86,01,727,055	0.000,527,908
	HUS1	− 86,01,727,055	0.000,527,908
	UBXN6	− 85,98,645,224	0.000,102,859
	CERCAM	− 85,61,137,856	0.000,358,764
	DOCK11	− 85,61,137,856	0.000,358,764
	C3P1	− 84,44,523,505	1.52E−09
	TBCD	− 84,44,523,505	1.52E−09
	C1QTNF9	− 84,32,653,935	0.000,000,467
	IARS1	− 84,11,532,069	2.29667E−06
	BSPRY	− 83,73,678,607	0.000,156,053
	TFE3	− 83,73,678,607	0.000,156,053
	SMARCA2	− 83,57,182,955	0.000,004,115
	CCDC62	− 83,11,684,461	9.48193E−09
	FAM117B	− 83,11,684,461	9.48193E−09
	DENND2B	− 83,11,642,437	0.000,501,791
	ZNF462	− 82,62,363,647	0.000,132,237
	ARID2	− 81,88,091,076	0.000,330,603
	LRRTM1	− 81,88,091,076	0.000,330,603
	SPON1	− 80,65,841,688	0.00,000,314
	VPS4B	− 80,51,171,134	0.0,000,114
Top 50 of the genes hypomethylated	EFCAB2	77,73,232,951	0.001,120,107
	DGKD	78,91,166,751	0.000,352,854
	LOC283683	78,91,166,751	0.000,352,854
	DLX2	81,76,085,867	0.000,213,868
	CAMSAP3	84,37,216,271	0.000,563,998
	SLC25A10	84,37,216,271	0.000,563,998
	CACTIN-AS1	84,99,735,616	3.18E−08
	RPS7	85,01,990,768	0.0,004,312
	CCDC110	85,65,159,895	0.000,654,831
	TMEM184B	87,1,437,235	0.000,244,851
	CYBC1	88,63,637,014	0.000,616,386
	MUC16	88,63,637,014	0.000,616,386
	MLIP	88,69,043,414	0.000,146,656
	DOCK10	90,28,688,782	0.0,000,496
	MMP17	90,28,688,782	0.0,000,496
	HIF3A	90,90,923,198	0.0,000,676
	SMOX	90,90,923,198	0.0,000,676
	GMCL1	94,26,290,015	0.00,000,577
	ITPR2	94,26,290,015	0.00,000,577
	LINC00205	98,14,808,839	1.0035E−06
	SPON2	98,14,808,839	1.0035E−06
	TARBP2	98,27,592,303	0.000,171,639
	EMD	99,84,144,366	0.000,046
	BCOR	100	0.000,443,279
	CDC42BPA	100	0.0,000,146
	FAF1	100	0.000,133,428
	FGD5	100	0.0,000,146
	GALNT8	100	0.000,358,708
	GSEC	100	0.0,000,634
	HMGXB3	100	0.000,204,717
	INTS11	100	0.0,000,194
	KMT2A	100	0.000,063
	MAN2A1	100	0.0,000,981
	NFKBIL1	100	0.000,133,428
	POMT2	100	0.0,000,159
	PPM1B	100	0.000,358,708
	PTPRE	100	0.000,725,654
	RASA2	100	0.000,533,106
	SDC3	100	0.0,000,566
	SERPINB9P1	100	0.0,000,566
	SH2B2	100	1.12E−19
	SLC27A2	100	4.92E−21
	TMEM222	100	1.09E−26
	TMEM242	100	0.001,111,454
	TMUB2	100	0.000,063
	TNRC6A	100	0.000,533,106
	TTC23	100	0.0,000,981
	TTLL6	100	0.0,000,634
	UNC5A	100	0.0,000,159
	XPR1	100	0.001,111,454

Back to article page

ISSN: 1868-7083

Contact us

Submission enquiries: avalyn.villar@springernature.com
General enquiries: info@biomedcentral.com

Clinical Epigenetics

Contact us