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Fig. 3 | Clinical Epigenetics

Fig. 3

From: A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease

Fig. 3

Cis-methylation quantitative trait loci relationship. The different boxplots indicate the relationship of the three common PON1 polymorphism associated CpG sites rs705379:C > T, rs854560:A > T, rs662:T > C in a population of patients with a wide range of (hepato)metabolic derangements. A total of 45 liver biopsies were analysed for which genotype distribution over the three PON1 variants is as follows: 27% CC, 58% CT and 15% TT for rs705379:C > T; 22% TT, 42% AT and 36% AA for rs854560:A > T; and 47% TT, 42% CT and 11% CC for rs662:T > C. Methylation is represented as M-values; positive M-values mean that more molecules are methylated than unmethylated (> 50% methylation) while negative M-values mean the opposite (< 50% methylation). Significance is determined by linear regression after which Benjamini–Hochberg is used to limit the false discoveries to 5% (q < 0.05)

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Clinical Epigenetics

ISSN: 1868-7083

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