Childhood growth and development and DNA methylation age in mid-life

Clinical Epigenetics

Table 2 DNAm age acceleration at 53 years and conditional growth

	N	AgeAccelHannum		AgeAccelHorvath		AgeAccelLevine		AgeAccelGrim
	N	Coefficient (95% CI)	P value	Coefficient (95% CI)	P valve	Coefficient (95% CI)	P value	Coefficient (95% CI)	P value
Relative weight gain
RWG between birth and 2 years	1127	− 0.09 (− 0.34, 0.16)	0.48	− 0.09 (− 0.34, 0.15)	0.44	− 0.05 (− 0.39, 0.29)	0.76	− 0.08 (− 0.38, 0.22)	0.62
RWG between 2 and 4 years	1065	0.11 (− 0.15, 0.37)	0.41	0.18 (− 0.07, 0.43)	0.16	− 0.07 (− 0.42, 0.28)	0.69	− 0.11 (− 0.42, 0.19)	0.47
RWG between 4 and 7 years	1168	− 0.17 (− 0.43, 0.08)	0.18	− 0.08 (− 0.33, 0.16)	0.51	0.05 (− 0.29, 0.40)	0.76	0.08 (− 0.23, 0.39)	0.60
RWG between 7 and 15 years	1161	0.16 (− 0.08, 0.40)	0.19	− 0.01 (− 0.24, 0.23)	0.94	0.22 (− 0.11, 0.54)	0.19	0.50 (0.20, 0.79)	< 0.001*
Linear growth
CLG between 2 and 4 years	1085	− 0.06 (− 0.31, 0.20)	0.67	0.07 (− 0.18, 0.32)	0.57	− 0.39 (− 0.74, − 0.04)	0.03**	− 0.24 (− 0.55, 0.06)	0.12
CLG between 4 and 7 years	1204	0.11 (− 0.12, 0.33)	0.36	− 0.04 (− 0.26, 0.19)	0.75	0.16 (− 0.15, 0.47)	0.32	0.01 (− 0.27, 0.28)	0.97
CLG between 7 and 15 years	1174	0.11 (− 0.13, 0.35)	0.36	0.03 (− 0.20, 0.26)	0.78	0.01 (− 0.31, 0.33)	0.97	0.14 (− 0.15, 0.43)	0.35

Adjusted for age in months at 53 years and sex. RWG: Relative weight gain, i.e. standardised residuals from regression of present weight z-score on previous weight and height z-scores and present height z-score
CLG: Conditional linear growth, i.e. standardised residuals from regression of present height z-score on previous height and weight z-scores
*p = 0.04 after Bonferroni correction
**p = 1.0 after Bonferroni correction

ISSN: 1868-7083