Aorta-specific DNA methylation patterns in cell-free DNA from patients with bicuspid aortic valve-associated aortopathy

Table 2 Four candidate aorta-specific DMRs

DMR				Mean methylation difference (%)
Chr	Start position	Length	CpG	Non-aortic tissues	Hematopoietic cells
11	3,168,734	73	6	70.60	92.75
18	74,171,459	46	8	74.26	91.27
20	45,860,400	65	6	86.88	81.01
22	27,999,645	72	7	75.36	91.28

Data presented for the four DMRs studied include chromosomal location, length (in base pairs), number of CpG sites and methylation differences between the aorta and pooled non-aortic tissues and hematopoietic cells as determined computationally. All DMRs presented are hypomethylated in the aorta compared to non-aortic tissues and hematopoietic cells.
Chr, chromosome; CpG, cytosine–guanine nucleotides

ISSN: 1868-7083