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Table 1 Population/sample description

From: Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction

Cases characteristics No Mean (SD) or % CONTROLS characteristics No Mean (SD) or % p-value*
Age (years) 40 69.8 (± 7.6) Age (years) 43 63.9 (± 9.8) 0.01*
Sex    Sex    0.51
 Female 15 37.5% Female 20 46.5%  
 Male 25 62.5% Male 23 53.5%  
Hystology    Hystology    0.05
 TB 23 57.5% TB 15 34.9%  
 TBV/V 17 42.5% TBV/V 28 65.1%  
Dysplasia Grade    Dysplasia Grade    1.0
 High 7 17.5% High 8 18.6%  
 Low 33 82.5% Low 35 81.4%  
Diameter (mm) 38 17.2 (± 9.0) Diameter (mm) 43 9.7 (± 6.7) 0.0002***
No Polyps 40 1.7 (± 0.9) N° Polyps 43 1.6 (± 1.0) 0.15
Localization    Localization    0.63
 Right 15 37.5% Right 15 34.9%  
 Left 25 62.5% Left 27 62.8%  
Year Adenoma 40 2008 (± 4.1) Year Adenoma 43 2007 (± 4.8) 0.89
Year CRC 40 2013 (± 2.6) Year FOLLOW-UP 43 2018
Mutational status    Mutational Status    0.49
 Wild Type 23 57.5% Wild Type 29 67.4%  
 Mutated 16 40.0% Mutated 14 32.6%  
 Transversions 9 56.2% Transversions 5 35.7% 0.46
 Transitions 7 43.7% Transitions 8 57.1%  
L1 Methylation    L1 Methylation    
 Global 40 58.9 (± 5.3) Global 43 60.9 (± 4.4) 0.05
 Intragenic 29 58.5 (± 2.3) Intragenic 43 60.0 (± 4.5) 0.14
L1 Methylation    L1 Methylation    
 Global (≤ 60%) 24 60.0% Global (≤ 60%) 19 44.2% 0.19
 Intragenic (≤ 60%) 23 79.1% Intragenic (≤ 60%) 24 55.8% 0.05
  1. SD = standard deviation, TB = tubular, TBV = tubulovillous, V = villous
  2. *pvalue were obtained by Mann–Whitney Test for continuous variables and by Fisher Test for categorical variables