Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction

Table 1 Population/sample description

Cases characteristics	No	Mean (SD) or %	CONTROLS characteristics	No	Mean (SD) or %	p-value*
Age (years)	40	69.8 (± 7.6)	Age (years)	43	63.9 (± 9.8)	0.01*
Sex			Sex			0.51
Female	15	37.5%	Female	20	46.5%
Male	25	62.5%	Male	23	53.5%
Hystology			Hystology			0.05
TB	23	57.5%	TB	15	34.9%
TBV/V	17	42.5%	TBV/V	28	65.1%
Dysplasia Grade			Dysplasia Grade			1.0
High	7	17.5%	High	8	18.6%
Low	33	82.5%	Low	35	81.4%
Diameter (mm)	38	17.2 (± 9.0)	Diameter (mm)	43	9.7 (± 6.7)	0.0002***
No Polyps	40	1.7 (± 0.9)	N° Polyps	43	1.6 (± 1.0)	0.15
Localization			Localization			0.63
Right	15	37.5%	Right	15	34.9%
Left	25	62.5%	Left	27	62.8%
Year Adenoma	40	2008 (± 4.1)	Year Adenoma	43	2007 (± 4.8)	0.89
Year CRC	40	2013 (± 2.6)	Year FOLLOW-UP	43	2018	–
Mutational status			Mutational Status			0.49
Wild Type	23	57.5%	Wild Type	29	67.4%
Mutated	16	40.0%	Mutated	14	32.6%
Transversions	9	56.2%	Transversions	5	35.7%	0.46
Transitions	7	43.7%	Transitions	8	57.1%
L1 Methylation			L1 Methylation
Global	40	58.9 (± 5.3)	Global	43	60.9 (± 4.4)	0.05
Intragenic	29	58.5 (± 2.3)	Intragenic	43	60.0 (± 4.5)	0.14
L1 Methylation			L1 Methylation
Global (≤ 60%)	24	60.0%	Global (≤ 60%)	19	44.2%	0.19
Intragenic (≤ 60%)	23	79.1%	Intragenic (≤ 60%)	24	55.8%	0.05

SD = standard deviation, TB = tubular, TBV = tubulovillous, V = villous
^*pvalue were obtained by Mann–Whitney Test for continuous variables and by Fisher Test for categorical variables

ISSN: 1868-7083