|
Cases characteristics
|
No
|
Mean (SD) or %
|
CONTROLS characteristics
|
No
|
Mean (SD) or %
|
p-value*
|
|---|
|
Age (years)
|
40
|
69.8 (± 7.6)
|
Age (years)
|
43
|
63.9 (± 9.8)
|
0.01*
|
|
Sex
| | |
Sex
| | |
0.51
|
|
Female
|
15
|
37.5%
|
Female
|
20
|
46.5%
| |
|
Male
|
25
|
62.5%
|
Male
|
23
|
53.5%
| |
|
Hystology
| | |
Hystology
| | |
0.05
|
|
TB
|
23
|
57.5%
|
TB
|
15
|
34.9%
| |
|
TBV/V
|
17
|
42.5%
|
TBV/V
|
28
|
65.1%
| |
|
Dysplasia Grade
| | |
Dysplasia Grade
| | |
1.0
|
|
High
|
7
|
17.5%
|
High
|
8
|
18.6%
| |
|
Low
|
33
|
82.5%
|
Low
|
35
|
81.4%
| |
|
Diameter (mm)
|
38
|
17.2 (± 9.0)
|
Diameter (mm)
|
43
|
9.7 (± 6.7)
|
0.0002***
|
|
No Polyps
|
40
|
1.7 (± 0.9)
|
N° Polyps
|
43
|
1.6 (± 1.0)
|
0.15
|
|
Localization
| | |
Localization
| | |
0.63
|
|
Right
|
15
|
37.5%
|
Right
|
15
|
34.9%
| |
|
Left
|
25
|
62.5%
|
Left
|
27
|
62.8%
| |
|
Year Adenoma
|
40
|
2008 (± 4.1)
|
Year Adenoma
|
43
|
2007 (± 4.8)
|
0.89
|
|
Year CRC
|
40
|
2013 (± 2.6)
|
Year FOLLOW-UP
|
43
|
2018
|
–
|
|
Mutational status
| | |
Mutational Status
| | |
0.49
|
|
Wild Type
|
23
|
57.5%
|
Wild Type
|
29
|
67.4%
| |
|
Mutated
|
16
|
40.0%
|
Mutated
|
14
|
32.6%
| |
|
Transversions
|
9
|
56.2%
|
Transversions
|
5
|
35.7%
|
0.46
|
|
Transitions
|
7
|
43.7%
|
Transitions
|
8
|
57.1%
| |
|
L1 Methylation
| | |
L1 Methylation
| | | |
|
Global
|
40
|
58.9 (± 5.3)
|
Global
|
43
|
60.9 (± 4.4)
|
0.05
|
|
Intragenic
|
29
|
58.5 (± 2.3)
|
Intragenic
|
43
|
60.0 (± 4.5)
|
0.14
|
|
L1 Methylation
| | |
L1 Methylation
| | | |
|
Global (≤ 60%)
|
24
|
60.0%
|
Global (≤ 60%)
|
19
|
44.2%
|
0.19
|
|
Intragenic (≤ 60%)
|
23
|
79.1%
|
Intragenic (≤ 60%)
|
24
|
55.8%
|
0.05
|
- SD = standard deviation, TB = tubular, TBV = tubulovillous, V = villous
- *pvalue were obtained by Mann–Whitney Test for continuous variables and by Fisher Test for categorical variables
