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Table 5 The relationship between CpGs methylation and PFS in advanced HGSOC

From: Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer

CpGid Advanced HGSOC (the total group) Advanced HGSOC with complete debulking Advanced HGSOC with incomplete debulking
Mean (months) 95% CI P Mean (months) 95% CI P Mean (months) 95% CI P
cg21105318          
Hypomethylation 22.98 19.43–26.52 0.020 25.63 22.65–28.60 0.086 20.33 12.63–28.04 0.08
Hypermethylation 16.18 13.13–19.23   18.07 14.00–22.14   12.39 9.00–15.78  
cg07896068          
Hypomethylation 20.55 17.44–23.66 0.006 23.50 19.92–27.09 0.004 16.14 11.04–21.25 0.343
Hypermethylation 13.66 9.74–17.57   14.14 8.43–19.86   12.30 8.04–16.56  
cg27637873          
Hypomethylation 21.36 18.02–24.70 0.010 23.89 20.20–27.58 0.015 16.67 10.43–22.91 0.437
Hypermethylation 15.18 11.59–18.78   16.27 11.00–21.53   13.00 9.10–16.90  
cg26782361          
Hypomethylation 20.66 17.33–23.99 0.019 22.86 18.89–26.83 0.068 17.17 11.55–22.79 0.168
Hypermethylation 15.08 11.35–18.81   17.18 11.84–22.51   11.25 8.04–14.46  
cg16265707          
Hypomethylation 20.37 17.21–23.52 0.013 22.89 19.27–26.52 0.022 16.23 10.76–21.71 0.309
Hypermethylation 14.37 10.41–18.33   16.14 10.22–22.06   12.55 8.56–16.53  
cg20937934          
Hypomethylation 21.97 18.07–25.87 0.023 24.30 20.15–28.45 0.073 18.00 10.04–25.96 0.212
Hypermethylation 15.63 12.35–18.91   16.80 12.19–21.42   12.88 9.44–16.33