Skip to main content

Table 1 KEGG and BIOCARTA pathways associated with nc886-3p and -5p expression

From: Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs

Gene set name # Genes in gene set (K) # Genes in Overlap (k) k/K p value FDR q value
nc886-3p      
KEGG_ENDOCYTOSIS 181 8 0.044 4.37 × 10–6 0.002
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 96 6 0.063 9.99 × 10–6 0.002
KEGG_CHRONIC_MYELOID_LEUKEMIA 73 5 0.069 3.62 × 10–5 0.004
KEGG_INSULIN_SIGNALING_PATHWAY 137 6 0.044 7.46 × 10–5 0.005
KEGG_FOCAL_ADHESION 199 7 0.035 7.51 × 10–5 0.005
nc886-5p      
KEGG_INOSITOL_PHOSPHATE_METABOLISM 54 6 0.111 3.53*10–7 1.68 × 10–4
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 76 6 0.079 2.72 × 10–6 0.001
KEGG_ACUTE_MYELOID_LEUKEMIA 57 5 0.088 1.13 × 10–5 0.002
Both nc886-3p and nc886-5p      
KEGG_ACUTE_MYELOID_LEUKEMIA 57 7 0.123 1.23 × 10–6 0.001
BIOCARTA_ERK_PATHWAY 27 5 0.185 5.36 × 10–6 0.001
KEGG_INOSITOL_PHOSPHATE_METABOLISM 54 6 0.111 1.31 × 10–5 0.002
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 96 7 0.073 4.04 × 10–5 0.004
KEGG_INSULIN_SIGNALING_PATHWAY 137 8 0.058 5.66 × 10–5 0.004
KEGG_PATHWAYS_IN_CANCER 325 12 0.037 8.20 × 10–5 0.004
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 76 6 0.079 9.28 × 10–5 0.004
KEGG_FOCAL_ADHESION 199 9 0.045 1.42 × 10–4 0.006
KEGG_HEMATOPOIETIC_CELL_LINEAGE 87 6 0.069 1.96 × 10–4 0.008
KEGG_ENDOCYTOSIS 181 8 0.044 3.85 × 10–4 0.012
KEGG_CHRONIC_MYELOID_LEUKEMIA 73 5 0.069 0.001 0.021
BIOCARTA_MAPK_PATHWAY 81 5 0.062 0.001 0.028
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 213 8 0.038 0.001 0.028
KEGG_CHEMOKINE_SIGNALING_PATHWAY 189 7 0.037 0.002 0.044
  1. Gene set enrichment was analyzed for genes that were predicted targets of nc886-3p/nc886-5p according to mircoRNA.org and whose RNA levels correlated (spearman rank order correlation) with the targeting ncRNA at the level of p < 0.05. Pathways with FDR < 0.05 and more than five genes overlapping are presented in the table