Table 7 Timing of testosterone replacement therapy on DNA methylation in individuals with 49,XXXXY
From: DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study
MAOA | Received < 60 (N = 11) | Booster 60–107 (N = 4) | Megabooster 108–131 (N = 3) | 132 + (N = 3) | |||
|---|---|---|---|---|---|---|---|
% Methylation change (95% CI) | P value | % Methylation change (95% CI) | P value | % Methylation change (95% CI) | P value | ||
CpG-1 | Ref | 0.37 (− 6.58, 7.32) | 0.92 | 4.04 (− 2.45, 10.53) | 0.25 | − 6.13 (− 2.45, 14.70) | 0.19 |
CpG-2 | Ref | − 1.17 (− 7.11, 4.77) | 0.71 | 2.49 (− 3.29, 8.27) | 0.42 | 5.82 (− 1.39, 13.04) | 0.15 |
CpG-3 | Ref | − 1.83 (− 9.38, 5.72) | 0.64 | 3.14 (− 4.24, 10.52) | 0.42 | 10.05 (1.85, 18.24) | 0.04 |
CpG-4 | Ref | − 0.9 (− 6.89, 6.71) | 0.98 | − 0.33 (− 7.13, 6.46) | 0.93 | 4.38 (− 4.38, 13.13) | 0.35 |
CpG-5 | Ref | 1.56 (− 2.16, 5.27) | 0.43 | 2.09 (− 1.52, 5.71) | 0.28 | 4.06 (− 0.47, 8.58) | 0.11 |
CpG-6 | Ref | − 3.88 (− 13.61, 5.84) | 0.45 | 0.23 (− 9.79, 10.25) | 0.97 | 5.61 (− 7.45, 18.66) | 0.42 |
CpG-7 | Ref | 5.76 (1.61, 9.91) | 0.02 | 0.75 (− 4.71, 6.20) | 0.79 | 0.73 (− 6.65, 8.10) | 0.85 |
AR | Â | Â | Â | Â | Â | Â | Â |
CpG-1 | Ref | 6.46 (− 5.49, 18.42) | 0.31 | − 4.61 (− 16.80, 7.78) | 0.49 | − 2.18 (− 19.12, 14.77) | 0.81 |
CpG-2 | Ref | 3.97 (− 14.25, 22.19) | 0.69 | 9.43 (− 8.01, 26.86) | 0.31 | 17.53 (− 4.76, 39.81) | 0.15 |
CpG-3 | Ref | − 0.34 (− 15.22, 14.53) | 0.97 | 8.39 (− 5.55, 22.32) | 0.27 | 16.43 (− 0.84, 33.71) | 0.09 |
CpG-4 | Ref | 4.26 (− 18.00, 26.52) | 0.72 | 12.41 (− 8.65, 33.47) | 0.28 | 28.37 (3.78, 52.96) | 0.05 |