Table 6 Effect of testosterone replacement therapy on DNA methylation in individuals with 49,XXXXY
From: DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study
MAOA | Did not receive T | Received < 60 (N = 11) | Booster 60–107 (N = 4) | Megabooster 108–131 (N = 3) | 132 + (N = 3) | ||||
|---|---|---|---|---|---|---|---|---|---|
Methylation % change (95% CI) | P value | Methylation % change (95% CI) | P value | Methylation % change (95% CI) | P value | Methylation % change (95% CI) | P value | ||
CpG-1 | Ref | 2.365 (− 1.15, 5.88) | 0.20 | − 1.95 (− 6.50, 2.60) | 0.41 | 2.60 (− 3.49, 8.69) | 0.41 | − 0.53 (− 6.73, 5.66) | 0.87 |
CpG-2 | Ref | 6.52 (1.59, 9.24) | 0.01 | 1.07 (− 4.62, 6.77) | 0.72 | − 0.27 (− 7.92, 7.37) | 0.95 | 6.93 (− 0.06, 13.91) | 0.07 |
CpG-3 | Ref | 4.02 (− 0.36, 8.40) | 0.09 | − 4.44 (− 10.07, 1.19) | 0.14 | 0.99 (− 6.99, 8.97) | 0.81 | 1.67 (− 6.28, 9.63) | 0.069 |
CpG-4 | Ref | 6.41 (0.50, 12.32) | 0.047 | 1.83 (− 6.41, 10.07) | 0.67 | − 3.34 (− 14.32, 7.63) | 0.56 | 6.45 (− 4.24, 17.15) | 0.25 |
CpG-5 | Ref | 0.38 (− 1.57, 2.32) | 0.71 | 0.13 (− 2.33, 2.59) | 0.92 | 1.75 (− 1.45, 4.94) | 0.30 | − 0.42 (− 3.70, 2.86) | 0.81 |
CpG-6 | Ref | 2.11 (− 2.24, 6.46) | 0.35 | − 2.00 (− 7.55, 3.53) | 0.49 | − 0.79 (− 8.29, 6.71) | 0.84 | 5.10 (− 2.06, 12.25) | 0.18 |
CpG-7 | Ref | − 0.95 (− 4.18, 2.28) | 0.57 | 2.74 (− 1.17, 6.66) | 0.19 | 1.14 (− 4.33, 6.61) | 0.69 | 1.93 (− 3.50, 7.35) | 0.50 |