Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers

Table 1 Population description

	Group 1 (n = 16)	Group 2 (n = 16)	Group 3 (n = 13)	Comparison 1 vs 2 (p =)	Comparison 1 vs 3 (p =)	Comparison 2 vs 3 (p =)
Age (years)	69.0 ± 9.5	58.8 ± 6.1	60.4 ± 14.9	0.002	ns	ns
ITAC	Yes	No	No
Wood dust exposure	Yes	Yes	No
Exposure duration (years)	32.2 ± 17.9	43.3 ± 6.3		0.0257	-	-
Delay/first exposure (years)	54.5 ± 9.6	36.2 ± 28.5		0.0005	-	-
Other carcinogens
Tobacco (current use) (n =)	2	2	1	ns	ns	ns
Tobacco (current or former use) (n =)	12	8	7	ns	ns	ns
Asbestos exposure (n =)	2	2	4	ns	ns	ns
Other carcinogen (formaldehyde…) (n =)	1	1	1	ns	ns	ns

Woodworkers with adenocarcinomas were slightly older than controls. The latency was longer in group 1 than in group 2, while exposure duration was longer in group 2. There were no other difference between groups in particular in the wood types processed or in woodworkers activities for group 1 and 2

ISSN: 1868-7083