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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Chromatin accessibility changes at intergenic regions are associated with ovarian cancer drug resistance

Fig. 1

Correlation of ATAC-seq chromatin accessibility profiles across ovarian cancer cell lines. Heatmaps of ATAC-seq coverage in regions showing differential accessibility between the cisplatin-sensitive and cisplatin-resistant line in each pair. Each row is a 1-Kb window showing log2FC > ± 2 and FDR < 0.001. Dendrograms show similarity between samples as defined by unsupervised hierarchical clustering a A2780/CP70, b PEA1/PEA2, c PEO1/PEO4. d Heatmap of Spearman’s correlation coefficients for each experimental replicate for each cell line analyzed, based on all windows passing filter

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Clinical Epigenetics

ISSN: 1868-7083

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