Fig. 2
From: The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium
In vitro decidualization and the regulation of epigenetic processes. On the left side of the figure are shown the different methodologies used to induce in vitro decidualization. On the right side of the figure are shown the effects of in vitro decidualization on the content of epigenetic processes and components. Estradiol and progesterone downregulate the expression of DNMT1 (mainly by progesterone) and DNMT3b (mainly by estradiol), increase the enrichment H3K27ac and H3K4me3 in the promoter regions of genes associated with insulin signaling, increase the global content of H3K27ac and H3K4me1, and decrease the global content of H3K4me3. Progesterone and cAMP increase the enrichment of H3K27me3 in the promoter region of WNT4, ZBTB16, PROK1, and GREB1 genes. Estradiol, progesterone, and cAMP downregulate the expression of DNMT3b and transiently decrease the expression of DNMT1 and DNMT3a