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Table 3 Univariable Cox proportional hazards regression survival analyses of different NEFM DNA methylation loci in TCGA BRCA HumanMethylation450K platform

From: NEFM DNA methylation correlates with immune infiltration and survival in breast cancer

VarNames

UCSC_RefGene_Group

Relation_to_UCSC_CpG_Island

HR

CI95

p

NEFMmet

  

1.6

1.03–2.48

0.036

cg01583969

5'UTR;Body

S_Shore

1.47

0.95–2.28

0.086

cg02002551

5'UTR;Body

S_Shore

1.14

0.74–1.76

0.545

cg02106941

TSS1500;1stExon

Island

0.97

0.63–1.49

0.888

cg02761376

TSS1500;1stExon

Island

1.56

1.01–2.42

0.045

cg03012544

Body;Body

S_Shore

1.14

0.74–1.75

0.555

cg03169018

TSS200;Body

Island

1.2

0.78–1.84

0.412

cg04118306

TSS200;1stExon

Island

0.97

0.63–1.49

0.885

cg07502389

TSS200;TSS1500

Island

1.76

1.14–2.74

0.012

cg07552803

TSS1500;1stExon

Island

1.31

0.85–2.02

0.216

cg09234518

TSS200;TSS1500

Island

1.96

1.25–3.07

0.003

cg12026749

5'UTR;Body

S_Shore

1.24

0.8–1.9

0.335

cg13387869

3'UTR;3'UTR

S_Shelf

0.84

0.55–1.29

0.424

cg16459364

TSS200;TSS1500

Island

1.14

0.74–1.76

0.557

cg17078116

TSS200;1stExon

Island

1.11

0.72–1.7

0.647

cg18267374

TSS1500;5'UTR;1stExon

Island

1.75

1.13–2.72

0.013

cg18898125

TSS1500

N_Shore

1.22

0.79–1.87

0.368

cg19677607

TSS200;1stExon

Island

1.6

1.03–2.48

0.038

cg20585869

TSS200;1stExon

Island

0.78

0.5–1.2

0.261

cg22562942

TSS200;1stExon

Island

1.35

0.87–2.1

0.181

cg23290344

TSS1500;1stExon

Island

1.34

0.87–2.06

0.188

cg24705551

Body;Body

S_Shelf

1.12

0.73–1.72

0.596

cg26330518

TSS1500

N_Shore

1.56

1.01–2.41

0.044

cg26980244

5'UTR;1stExon;Body

Island

1.42

0.92–2.19

0.116

cg27475652

Body;Body

S_Shelf

1.04

0.67–1.6

0.867

  1. HR: hazard ratio; CI 95: 95% confidence interval. Significant p Values < 0.05 are in bold. NEFMmet: mean beta value of all DNA methylation loci of NEFM. Seven DNA methylation loci of NEFM including NEFMmet were connected with survival