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Table 3 Univariable Cox proportional hazards regression survival analyses of different NEFM DNA methylation loci in TCGA BRCA HumanMethylation450K platform

From: NEFM DNA methylation correlates with immune infiltration and survival in breast cancer

VarNames UCSC_RefGene_Group Relation_to_UCSC_CpG_Island HR CI95 p
NEFMmet    1.6 1.03–2.48 0.036
cg01583969 5'UTR;Body S_Shore 1.47 0.95–2.28 0.086
cg02002551 5'UTR;Body S_Shore 1.14 0.74–1.76 0.545
cg02106941 TSS1500;1stExon Island 0.97 0.63–1.49 0.888
cg02761376 TSS1500;1stExon Island 1.56 1.01–2.42 0.045
cg03012544 Body;Body S_Shore 1.14 0.74–1.75 0.555
cg03169018 TSS200;Body Island 1.2 0.78–1.84 0.412
cg04118306 TSS200;1stExon Island 0.97 0.63–1.49 0.885
cg07502389 TSS200;TSS1500 Island 1.76 1.14–2.74 0.012
cg07552803 TSS1500;1stExon Island 1.31 0.85–2.02 0.216
cg09234518 TSS200;TSS1500 Island 1.96 1.25–3.07 0.003
cg12026749 5'UTR;Body S_Shore 1.24 0.8–1.9 0.335
cg13387869 3'UTR;3'UTR S_Shelf 0.84 0.55–1.29 0.424
cg16459364 TSS200;TSS1500 Island 1.14 0.74–1.76 0.557
cg17078116 TSS200;1stExon Island 1.11 0.72–1.7 0.647
cg18267374 TSS1500;5'UTR;1stExon Island 1.75 1.13–2.72 0.013
cg18898125 TSS1500 N_Shore 1.22 0.79–1.87 0.368
cg19677607 TSS200;1stExon Island 1.6 1.03–2.48 0.038
cg20585869 TSS200;1stExon Island 0.78 0.5–1.2 0.261
cg22562942 TSS200;1stExon Island 1.35 0.87–2.1 0.181
cg23290344 TSS1500;1stExon Island 1.34 0.87–2.06 0.188
cg24705551 Body;Body S_Shelf 1.12 0.73–1.72 0.596
cg26330518 TSS1500 N_Shore 1.56 1.01–2.41 0.044
cg26980244 5'UTR;1stExon;Body Island 1.42 0.92–2.19 0.116
cg27475652 Body;Body S_Shelf 1.04 0.67–1.6 0.867
  1. HR: hazard ratio; CI 95: 95% confidence interval. Significant p Values < 0.05 are in bold. NEFMmet: mean beta value of all DNA methylation loci of NEFM. Seven DNA methylation loci of NEFM including NEFMmet were connected with survival