Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

Sillanpää, Elina; Heikkinen, Aino; Kankaanpää, Anna; Paavilainen, Aini; Kujala, Urho M.; Tammelin, Tuija H.; Kovanen, Vuokko; Sipilä, Sarianna; Pietiläinen, Kirsi H.; Kaprio, Jaakko; Ollikainen, Miina; Laakkonen, Eija K.

doi:10.1186/s13148-021-01094-6

Table 5 Associations between DNAmAge age acceleration estimates, body composition and physical function in muscle

From: Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

		Muscle DNAmAge Acceleration
		Horvath			GrimAge			MEAT
		β (SE)	p-value	R²	β (SE)	p-value	R²	β (SE)	p-value	R²
FTC& ERMA (N = 186)
Body mass index,	Model 1	− 0.049 (0.050)	0.323	0.005	− 0.037 (0.020)	0.072	0.018	− 0.014 (0.047)	0.759	0.001
kg/m²	Model 2	− 0.047 (0.048)	0.334	0.014	− 0.036 (0.020)	0.070	0.034	− 0.011 (0.060)	0.848	0.002
Fat mass, kg	Model 1	− 0.058 (0.023)	0.012	0.029	− 0.020 (0.009)	0.036	0.024	− 0.006 (0.022)	0.780	0.000
	Model 2	− 0.050 (0.025)	0.048	0.009	− 0.018 (0.008)	0.029	0.038	− 0.007 (0.025)	0.788	0.003
Lean body mass, kg	Model 1	0.084 (0.027)	0.002	0.045	0.012 (0.011)	0.290	0.006	− 0.004 (0.026)	0.875	0.000
	Model 2	0.040 (0.052)	0.437	0.073	0.002 (0.019)	0.909	0.018	− 0.018 (0.048)	0.710	0.004
Fat percent, %	Model 1	− 0.107 (0.029)	< 0.001	0.064	− 0.030 (0.012)	0.014	0.032	0.008 (0.029)	0.771	0.001
	Model 2	− 0.078 (0.038)	0.042	0.098	− 0.028 (0.013)	0.041	0.039	0.011 (0.038)	0.771	0.003
FTC (N = 60)
Maximal oxygen	Model 1	0.117 (0.058)	0.048	0.066	0.037 (0.020)	0.074	0.054	− 0.077 (0.044)	0.082	0.051
uptake, ml/kg/min	Model 2	0.034 (0.069)	0.626	0.195	0.028 (0.032)	0.393	0.075	− 0.079 (0.042)	0.067	0.071
ERMA (N = 47)
Walking test 6 min	Model 1	0.002 (0.009)	0.811	0.001	0.007 (0.004)	0.138	0.050	− 0.005 (0.008)	0.506	0.009
M	Model 3	0.000 (0.009)	0.959	0.010	0.006 (0.005)	0.187	0.070	− 0.004 (0.008)	0.632	0.014
Hand grip strength	Model 1	0.001 (0.100)	0.904	0.000	0.000 (0.005)	0.959	0.000	− 0.012 (0.009)	0.203	0.036
N	Model 3	0.001 (0.010)	0.913	0.009	0.000 (0.005)	0.973	0.034	− 0.012 (0.009)	0.213	0.051
Knee extension	Model 1	0.010 (0.006)	0.098	0.066	0.004 (0.003)	0.170	0.044	− 0.003 (0.005)	0.508	0.007
torque, Nm	Model 3	0.010 (0.006)	0.115	0.074	0.004 (0.003)	0.285	0.066	− 0.004 (0.005)	0.486	0.056
Vertical jumping	Model 1	1.43 (12.95)	0.915	0.000	6.246 (6.545)	0.345	0.020	− 11.9 (12.0)	0.326	0.021
height, cm	Model 3	0.679 (13.3)	0.960	0.009	5.431 (6.664)	0.420	0.048	− 12.8 (12.3)	0.302	0.040

Model 1. Linear regression analysis with one predictor. Model 2. As Model one, but adjusted for family relatedness, sex and smoking. Model 3 as model one, but adjusted for smoking. MEAT, muscle epigenetic age test. FTC, Finnish twin cohort; ERMA, Estrogenic Regulation of Muscle Apoptosis study

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ISSN: 1868-7083

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