Muscle DNAmAge Acceleration | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Horvath | GrimAge | MEAT | ||||||||
β (SE) | p-value | R2 | β (SE) | p-value | R2 | β (SE) | p-value | R2 | ||
FTC& ERMA (N = 186) | ||||||||||
Body mass index, | Model 1 | − 0.049 (0.050) | 0.323 | 0.005 | − 0.037 (0.020) | 0.072 | 0.018 | − 0.014 (0.047) | 0.759 | 0.001 |
kg/m2 | Model 2 | − 0.047 (0.048) | 0.334 | 0.014 | − 0.036 (0.020) | 0.070 | 0.034 | − 0.011 (0.060) | 0.848 | 0.002 |
Fat mass, kg | Model 1 | − 0.058 (0.023) | 0.012 | 0.029 | − 0.020 (0.009) | 0.036 | 0.024 | − 0.006 (0.022) | 0.780 | 0.000 |
Model 2 | − 0.050 (0.025) | 0.048 | 0.009 | − 0.018 (0.008) | 0.029 | 0.038 | − 0.007 (0.025) | 0.788 | 0.003 | |
Lean body mass, kg | Model 1 | 0.084 (0.027) | 0.002 | 0.045 | 0.012 (0.011) | 0.290 | 0.006 | − 0.004 (0.026) | 0.875 | 0.000 |
Model 2 | 0.040 (0.052) | 0.437 | 0.073 | 0.002 (0.019) | 0.909 | 0.018 | − 0.018 (0.048) | 0.710 | 0.004 | |
Fat percent, % | Model 1 | − 0.107 (0.029) | < 0.001 | 0.064 | − 0.030 (0.012) | 0.014 | 0.032 | 0.008 (0.029) | 0.771 | 0.001 |
Model 2 | − 0.078 (0.038) | 0.042 | 0.098 | − 0.028 (0.013) | 0.041 | 0.039 | 0.011 (0.038) | 0.771 | 0.003 | |
FTC (N = 60) | ||||||||||
Maximal oxygen | Model 1 | 0.117 (0.058) | 0.048 | 0.066 | 0.037 (0.020) | 0.074 | 0.054 | − 0.077 (0.044) | 0.082 | 0.051 |
uptake, ml/kg/min | Model 2 | 0.034 (0.069) | 0.626 | 0.195 | 0.028 (0.032) | 0.393 | 0.075 | − 0.079 (0.042) | 0.067 | 0.071 |
ERMA (N = 47) | ||||||||||
Walking test 6 min | Model 1 | 0.002 (0.009) | 0.811 | 0.001 | 0.007 (0.004) | 0.138 | 0.050 | − 0.005 (0.008) | 0.506 | 0.009 |
M | Model 3 | 0.000 (0.009) | 0.959 | 0.010 | 0.006 (0.005) | 0.187 | 0.070 | − 0.004 (0.008) | 0.632 | 0.014 |
Hand grip strength | Model 1 | 0.001 (0.100) | 0.904 | 0.000 | 0.000 (0.005) | 0.959 | 0.000 | − 0.012 (0.009) | 0.203 | 0.036 |
N | Model 3 | 0.001 (0.010) | 0.913 | 0.009 | 0.000 (0.005) | 0.973 | 0.034 | − 0.012 (0.009) | 0.213 | 0.051 |
Knee extension | Model 1 | 0.010 (0.006) | 0.098 | 0.066 | 0.004 (0.003) | 0.170 | 0.044 | − 0.003 (0.005) | 0.508 | 0.007 |
torque, Nm | Model 3 | 0.010 (0.006) | 0.115 | 0.074 | 0.004 (0.003) | 0.285 | 0.066 | − 0.004 (0.005) | 0.486 | 0.056 |
Vertical jumping | Model 1 | 1.43 (12.95) | 0.915 | 0.000 | 6.246 (6.545) | 0.345 | 0.020 | − 11.9 (12.0) | 0.326 | 0.021 |
height, cm | Model 3 | 0.679 (13.3) | 0.960 | 0.009 | 5.431 (6.664) | 0.420 | 0.048 | − 12.8 (12.3) | 0.302 | 0.040 |