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Table 5 Associations between DNAmAge age acceleration estimates, body composition and physical function in muscle

From: Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

   Muscle DNAmAge Acceleration
Horvath GrimAge MEAT
β (SE) p-value R2 β (SE) p-value R2 β (SE) p-value R2
FTC& ERMA (N = 186)           
Body mass index, Model 1 − 0.049 (0.050) 0.323 0.005 − 0.037 (0.020) 0.072 0.018 − 0.014 (0.047) 0.759 0.001
kg/m2 Model 2 − 0.047 (0.048) 0.334 0.014 − 0.036 (0.020) 0.070 0.034 − 0.011 (0.060) 0.848 0.002
Fat mass, kg Model 1 − 0.058 (0.023) 0.012 0.029 − 0.020 (0.009) 0.036 0.024 − 0.006 (0.022) 0.780 0.000
  Model 2 − 0.050 (0.025) 0.048 0.009 − 0.018 (0.008) 0.029 0.038 − 0.007 (0.025) 0.788 0.003
Lean body mass, kg Model 1 0.084 (0.027) 0.002 0.045 0.012 (0.011) 0.290 0.006 − 0.004 (0.026) 0.875 0.000
  Model 2 0.040 (0.052) 0.437 0.073 0.002 (0.019) 0.909 0.018 − 0.018 (0.048) 0.710 0.004
Fat percent, % Model 1 − 0.107 (0.029)  < 0.001 0.064 − 0.030 (0.012) 0.014 0.032 0.008 (0.029) 0.771 0.001
  Model 2 − 0.078 (0.038) 0.042 0.098 − 0.028 (0.013) 0.041 0.039 0.011 (0.038) 0.771 0.003
FTC (N = 60)           
Maximal oxygen Model 1 0.117 (0.058) 0.048 0.066 0.037 (0.020) 0.074 0.054 − 0.077 (0.044) 0.082 0.051
uptake, ml/kg/min Model 2 0.034 (0.069) 0.626 0.195 0.028 (0.032) 0.393 0.075 − 0.079 (0.042) 0.067 0.071
ERMA (N = 47)           
Walking test 6 min Model 1 0.002 (0.009) 0.811 0.001 0.007 (0.004) 0.138 0.050 − 0.005 (0.008) 0.506 0.009
M Model 3 0.000 (0.009) 0.959 0.010 0.006 (0.005) 0.187 0.070 − 0.004 (0.008) 0.632 0.014
Hand grip strength Model 1 0.001 (0.100) 0.904 0.000 0.000 (0.005) 0.959 0.000 − 0.012 (0.009) 0.203 0.036
N Model 3 0.001 (0.010) 0.913 0.009 0.000 (0.005) 0.973 0.034 − 0.012 (0.009) 0.213 0.051
Knee extension Model 1 0.010 (0.006) 0.098 0.066 0.004 (0.003) 0.170 0.044 − 0.003 (0.005) 0.508 0.007
torque, Nm Model 3 0.010 (0.006) 0.115 0.074 0.004 (0.003) 0.285 0.066 − 0.004 (0.005) 0.486 0.056
Vertical jumping Model 1 1.43 (12.95) 0.915 0.000 6.246 (6.545) 0.345 0.020 − 11.9 (12.0) 0.326 0.021
height, cm Model 3 0.679 (13.3) 0.960 0.009 5.431 (6.664) 0.420 0.048 − 12.8 (12.3) 0.302 0.040
  1. Model 1. Linear regression analysis with one predictor. Model 2. As Model one, but adjusted for family relatedness, sex and smoking. Model 3 as model one, but adjusted for smoking. MEAT, muscle epigenetic age test. FTC, Finnish twin cohort; ERMA, Estrogenic Regulation of Muscle Apoptosis study