Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

Sillanpää, Elina; Heikkinen, Aino; Kankaanpää, Anna; Paavilainen, Aini; Kujala, Urho M.; Tammelin, Tuija H.; Kovanen, Vuokko; Sipilä, Sarianna; Pietiläinen, Kirsi H.; Kaprio, Jaakko; Ollikainen, Miina; Laakkonen, Eija K.

doi:10.1186/s13148-021-01094-6

Table 4 Associations between DNAmAge age acceleration estimates and physical activity in muscle

From: Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

		Muscle DNAmAge acceleration
		Horvath			GrimAge			MEAT
		β (SE)	p-value	R²	β (SE)	p-value	R²	β (SE)	p-value	R²
FTC& ERMA (N = 183)
MVPA
Low (ref)	Model 1			0.045			0.022			0.002
Medium		0.456 (0.661)	0.492		0.152 (0.273)	0.578		0.120 (0.631)	0.849
High		1.842 (0.660)	0.006		0.531 (0.272)	0.053		0.338 (0.630)	0.592
Low (ref)	Model 2			0.111			0.038			0.005
Medium		− 0.040 (0.667)	0.951		0.059 (0.299)	0.843		0.156 (0.683)	0.820
High		1.573 (0.786)	0.048		0.493 (0.268)	0.068		0.336 (0.682)	0.637
FTC (N = 136)
Leisure index	Model 1	0.584 (0.516)	0.259	0.010	0.008 (0.189)	0.967	0.000	− 0.763 (0.472)	0.109	0.018
	Model 2	0.483 (0.538)	0.372	0.109	− 0.019 (0.190)	0.922	0.025	− 0.740 (0.523)	0.161	0.020
Sport index	Model 1	0.899 (0.338)	0.009	0.050	0.068 (0.123)	0.592	0.002	− 0.221 (0.319)	0.491	0.004
	Model 2	0.756 (0.440)	0.091	0.136	0.042 (0.127)	0.740	0.026	− 0.216 (0.377)	0.569	0.006
ERMA (N = 47)
Monitored PA
MVPA, min	Model 1	0.030 (0.017)	0.079	0.067	0.021 (0.008)	0.013	0.129	0.023 (0.016)	0.163	0.043
	Model 3	0.032 (0.018)	0.075	0.080	0.022 (0.009)	0.014	0.161	0.021 (0.017)	0.226	0.049
Step counts per day	Model 1	0.003 (0.002)	0.114	0.055	0.002 (0.001)	0.007	0.153	0.001 (0.002)	0.548	0.008
	Model 3	0.003 (0.002)	0.105	0.068	0.002 (0.001)	0.006	0.189	0.001 (0.002)	0.758	0.028
Self-reported PA
Low (ref)	Model 1			0.075			0.002			0.056
Medium		3.22 (1.82)	0.084		0.296 (0.965)	0.761		2.82 (1.79)	0.122
High		2.92 (1.66)	0.085		0.200 (0.880)	0.821		1.58 (1.63)	0.338
Low (ref)	Model 2			0.082			0.035			0.079
Medium		3.21 (1.87)	0.093		0.209 (0.978)	0.832		2.70 (1.82)	0.144
High		2.96 (1.72)	0.094		0.101 (0.903)	0.912		1.34 (1.68)	0.428

Model 1. Linear regression analysis with one predictor. Model 2. As Model one, but adjusted for family relatedness, sex and smoking. Model 3. As model one, but adjusted for smoking. Step counts per day calculated per 100 counts. MEAT, muscle epigenetic age test. FTC, Finnish twin cohort; ERMA, Estrogenic Regulation of Muscle Apoptosis study. In first analysis, we formed tertiles based on the amount of moderate to vigorous physical activity (MVPA, ERMA cohort) and sport indexes (FTC cohort) and pooled the data from these two cohorts

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ISSN: 1868-7083

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