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Table 2 Detection of methylation markers, cg054 and SCG3, by TAM-MSP in plasma

From: Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors

ID

Diagnosis

cg054/ACTB copies

SCG3/ACTB copies

cg054 MAF (%)

SCG3 MAF (%)

Total MAF (%)

PCNSL_1

PCNSL

1/660

0/660

0.20

0.00

0.20

PCNSL_2

PCNSL

8/1867

15/1867

0.45

0.80

1.25

PCNSL_3

PCNSL

84/2496

79/2496

3.37

3.15

6.52

PCNSL_4

PCNSL

9/2071

32/2071

0.42

1.55

1.97

PCNSL_5

PCNSL

1408/2826

1127/2826

49.82

39.88

89.69

PCNSL_6

PCNSL

0/2131

0/2131

0.00

0.00

0.00

PCNSL_7

PCNSL

0/1536

0/1536

0.00

0.00

0.00

PCNSL_8

PCNSL

0/243

0/243

0.00

0.00

0.00

PCNSL_9

PCNSL

54/5158

0/5158

1.04

0.00

1.04

PCNSL_10

PCNSL

21/2051

0/2051

1.03

0.00

1.03

PCNSL_11

PCNSL

0/76

0/76

0.00

0.00

0.00

PCNSL_12

PCNSL

0/7829

0/7829

0.00

0.00

0.00

PCNSL_13

PCNSL

0/1744

0/1744

0.00

0.00

0.00

PCNSL_14

PCNSL

2/1846

0/1846

0.09

0.00

0.09

PCNSL_15

PCNSL

0/37

0/37

0.00

0.00

0.00

Other_1

GBM

2/1279

0/1279

0.14

0.00

0.14

Other_2

IGa

6/2468

40/2468

0.24

1.61

1.85

Other_3

GBM

0/687

0/687

0.00

0.00

0.00

Other_4

GBM

13/115

0/1115

1.18

0.00

1.18

Other_5

DMG

0/1093

0/1093

0.00

0.00

0.00

Healthy_1

NA

0/1756

4/1756

0.02

0.24

0.26

Healthy_2

NA

0/2099

16/2099

0.00

0.76

0.76

Healthy_3

NA

0/2414

0/2414

0.00

0.00

0.00

Healthy_4

NA

0/1373

19/1373

0.00

1.37

1.37

Healthy_5

NA

0/1529

0/1529

0.00

0.00

0.00

Healthy_6

NA

0/1307

0/1307

0.00

0.00

0.00

  1. PCNSL primary central nervous system lymphoma, MAF methylation allele frequency, other CNS tumors, GBM glioblastoma multiformae, DMG diffuse midline glioma, IG infiltrating glioma
  2. aH3-K27M mutation