Skip to main content

Table 2 Fold enrichment, biological processes and molecular functions of a few TH2B associated genes

From: Epigenetic landscape of testis specific histone H2B variant and its influence on sperm function

Gene name Protein name Fold enrichment p value GO biological process GO molecular function
CREM cAMP-responsive element modulator 6.74 6 × 10–4 DNA-binding transcription factor activity, Regulation of transcription, Signal transduction,Multicellular organism development, Spermatogenesis DNA binding, RNA polymerase II transcription factor activity, Transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
PRKAG2 5′-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) 5.9 7 × 10–4 ATP biosynthetic process, Fatty acid biosynthetic process, Intracellular signal transduction, Positive regulation of protein kinase activity, Regulation of glycolytic process, regulation of signal transduction AMP-activated protein kinase activity, AMP binding, ATP binding, cAMP-dependent protein kinase regulator activity, Phosphorylase kinase regulator activity [GO:0008607]; protein kinase activator activity
CDYL Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) 29.5 1 × 10–5 Negative regulation of peptidyl-lysine crotonylation, Random inactivation of X chromosome, Regulation of transcription, Spermatid development, spermatogenesis Chromatin binding, Crotonyl-CoA hydratase activity, Methylated histone binding, Protein binding, Transcription corepressor activity
CATSPERB Cation channel sperm-associated protein subunit beta (CatSper-beta) 5.06 7 × 10–4 Multicellular organism development, Response to progesterone, Sperm capacitation, Sperm-egg recognition CatSpercomplex,Integral component of sperm membrane
TSGA10 Testis-specific gene 10 protein (Testis development protein NYD-SP7) 5.9 3 × 10–4 Cell projection assembly, Spermatogenesis Protein binding
TSSK1B Testis-specific serine/threonine-protein kinase 1 5.9 3 × 10–4 Intracellular signal transduction, Multicellular organism development, Protein phosphorylation, Spermatid development ATP binding, Magnesium ion binding, Protein serine/threonine kinase activity