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Table 3 Differentially methylated cytosines (DMCs; q < 0.05) that were increased post-surgery versus pre-surgery

From: Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes

Chr Position Gene Pre-surgery methylation % Post-surgery methylation % P value q value Genic region CpG region
chr2 27,498,318 DNAJC5G 51.83 ± 9.21 89.02 ± 2.98 1.01E−09 0.00067 utr5 InterCpgi
chr7 20,830,624 SP8 1.30 ± 0.84 13.90 ± 1.02 2.01E−09 0.00076 Intergenic CpG_Island
chr1 228,504,058 OBSCN 42.29 ± 6.19 84.61 ± 2.99 3.28E−09 0.00109 Intron CpG_Island
chr10 119,271,421 EMX2OS 42.57 ± 2.47 68.77 ± 3.23 6.08E−09 0.00161 Intergenic InterCpgi
chr1 51,154,377 FAF1 92.12 ± 2.38 100 ± 0 1.16E−08 0.00220 Intron InterCpgi
chr2 11,925,218 LPIN1 0 ± 0 9.68 ± 1.23 1.55E−07 0.01243 Intron CpG_Island
chr1 240,347,650 FMN2 84.75 ± 4.18 99.35 ± 0.65 2.06E−07 0.01352 Intron InterCpgi
chr4 57,068,530 KIAA1211 83.59 ± 2.29 98.25 ± 1.13 1.89E−07 0.01352 utr5 InterCpgi
chr18 13,431,993 C18orf1 84.39 ± 3.53 100 ± 0 3.16E−07 0.01820 Intron InterCpgi
chr3 113,160,431 WDR52 13.71 ± 2.73 46.89 ± 6.19 3.49E−07 0.01886 Promoter CpG_Island
chr13 96,414,410 DNAJC3 90.20 ± 2.64 100 ± 0 5.33E−07 0.02357 Intron InterCpgi
chr1 197,108,554 ASPM 86.50 ± 4.35 100 ± 0 7.84E−07 0.03038 Intron InterCpgi
chr17 5,462,805 NLRP1 80.80 ± 5.66 99.05 ± 0.95 7.90E−07 0.03038 Exon InterCpgi
chr19 54,872,598 LAIR1 67.12 ± 6.27 93.87 ± 2.11 8.60E−07 0.03079 Exon InterCpgi
chr11 36,512,043 TRAF6 40.53 ± 4.68 65.66 ± 3.25 8.80E−07 0.03079 Exon InterCpgi
chr15 52,248,473 LEO1 18.60 ± 3.51 45.53 ± 4.24 9.21E−07 0.03131 Intron InterCpgi
chr22 50,919,564 ADM2 2.23 ± 0.81 11.87 ± 1.89 1.17E−06 0.03742 Promoter CpG_Island
chr7 135,258,846 NUP205 88.18 ± 3.66 100 ± 0 1.20E−06 0.03793 Intron InterCpgi
chr1 93,172,465 EVI5 83.13 ± 3.46 100 ± 0 1.42E−06 0.04189 Intron InterCpgi
chr12 133,125,172 FBRSL1 88.19 ± 3.33 100 ± 0 1.44E−06 0.04203 intron North_shore
chr5 137,729,043 KDM3B 84.36 ± 3.76 96.62 ± 1.45 1.52E−06 0.04294 Exon InterCpgi
chr3 9,989,586 PRRT3 45.47 ± 3.64 74.18 ± 3.58 1.49E−06 0.04294 Exon CpG_Island
chrX 66,764,054 AR 15.74 ± 4.49 42.72 ± 2.58 1.67E−06 0.04508 utr5 CpG_Island
chr1 91,184,127 BARHL2 0 ± 0 2.97 ± 0.83 1.81E−06 0.04740 Promoter CpG_Island
chr7 939,123 ADAP1 40.13 ± 9.99 74.26 ± 3.10 1.83E−06 0.04759 Exon South_shelf
chr1 34,642,648 C1orf94 0 ± 0 7.35 ± 2.25 2.04E−06 0.04785 utr5 CpG_Island
chr7 71,562,951 CALN1 81.90 ± 4.23 98.70 ± 1.30 1.96E−06 0.04785 Intron InterCpgi
chr14 105,353,824 KIAA0284 62.07 ± 7.36 90.15 ± 4.41 1.93E−06 0.04785 Exon South_shelf
  1. Data are mean ± SEM. The P value is calculated from the MethylSig analysis. The q value is generated by Benjamini–Hochberg multiple testing correction