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Table 3 Diagnostics by DNA methylation profiling of diffuse lower-grade gliomas with assigned methylation classes and subclasses (n = 126)

From: DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas

Methylation class Molecular biomarkers according to methylation profiling
IDHa wt (n = 20) IDH mut
(n = 106)
Codel.b
(n = 51)
MGMTc unmeth
(n = 24)
MGMT meth
(n = 102)
IDH glioma (n = 106)
 1p/19q codeleted oligodendroglioma 0 51 51 0 51
 Astrocytoma 0 48 0 7 41
 High-grade astrocytoma 0 7 0 2 5
Glioblastoma IDH wt (n = 15)
 Mesenchymal 3 0 0 3 0
 Midline 1 0 0 0 1
 MYCN 1 0 0 1 0
 RTK I 3 0 0 2 1
 RTK II 7 0 0 5 2
 Pleomorphic xanthoastrocytoma 1 0 0 0 1
 Low-grade glioma MYB/MYBL1 1 0 0 1 0
Control tissue 3 0 0 3 0
  1. aIDH, isocitrate dehydrogenase gene family, wildtype (wt) and mutated (mut)
  2. bCodel., complete codeletion of 1p/19q chromosomal arms
  3. cMGMT, O6-methylguanine-DNA methyltransferase promotor, methylated (meth) or unmethylated (unmeth)