Table 3 Diagnostics by DNA methylation profiling of diffuse lower-grade gliomas with assigned methylation classes and subclasses (n = 126)
From: DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas
Methylation class | Molecular biomarkers according to methylation profiling | ||||
|---|---|---|---|---|---|
IDHa wt (n = 20) | IDH mut (n = 106) | Codel.b (n = 51) | MGMTc unmeth (n = 24) | MGMT meth (n = 102) | |
IDH glioma (n = 106) | |||||
1p/19q codeleted oligodendroglioma | 0 | 51 | 51 | 0 | 51 |
Astrocytoma | 0 | 48 | 0 | 7 | 41 |
High-grade astrocytoma | 0 | 7 | 0 | 2 | 5 |
Glioblastoma IDH wt (n = 15) | |||||
Mesenchymal | 3 | 0 | 0 | 3 | 0 |
Midline | 1 | 0 | 0 | 0 | 1 |
MYCN | 1 | 0 | 0 | 1 | 0 |
RTK I | 3 | 0 | 0 | 2 | 1 |
RTK II | 7 | 0 | 0 | 5 | 2 |
Pleomorphic xanthoastrocytoma | 1 | 0 | 0 | 0 | 1 |
Low-grade glioma MYB/MYBL1 | 1 | 0 | 0 | 1 | 0 |
Control tissue | 3 | 0 | 0 | 3 | 0 |