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Table 5 Associations between the identified CpGs and classical cardiovascular risk factors (CVRFs) in the fixed-effects meta-analyses of the four samples

From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease

CpG Smoking BMI* HDL-C* LDL-C* TG* Glucose SBP DBP*  
cg21566642 − 1.61 9.55 × 10–3 7.69 × 10–4 − 1.10 × 10–3 − 4.17 × 10–4 2.32 × 10–4 2.30 × 10–3 7.97 × 10–3 Coefficient
4.22 × 10–2 2.65 × 10–3 1.21 × 10–3 4.09 × 10–4 1.95 × 10–4 4.20 × 10–4 9.02 × 10–4 1.67 × 10–3 SE*
 < 2.2 × 10–16 3.21 × 10–4 5.24 × 10–1 7.11 × 10–3 3.22 × 10–2 5.81 × 10–1 1.08 × 10–2 1.78 × 10–6 P
cg05575921 − 1.61 1.17 × 10–2 4.36 × 10–3 − 1.35 × 10–3 − 7.09 × 10–4 1.86 × 10–4 2.15 × 10–3 7.54 × 10–3 Coefficient
4.22 × 10–2 2.46 × 10–3 1.11 × 10–3 3.77 × 10–4 1.79 × 10–4 3.87 × 10–4 8.23 × 10–4 1.52 × 10–3 SE*
 < 2.2 × 10–16 2.22 × 10–6 8.22 × 10–5 3.39 × 10–4 7.63 × 10–5 6.30 × 10–1 9.06 × 10–3 7.69 × 10–7 P
cg25769469 − 9.01 × 10–2 − 1.12 × 10–2 6.76 × 10–3 2.47 × 10–4 − 1.38 × 10–3 − 1.52 × 10–3 − 2.35 × 10–3 − 4.17 × 10–3 Coefficient
5.08 × 10–2 2.64 × 10–3 1.20 × 10–3 4.11 × 10–4 1.93 × 10–4 4.17 × 10–4 9.10 × 10–4 1.69 × 10–3 SE*
7.65 × 10–2 2.32 × 10–5 1.92 × 10–8 5.48 × 10–1 8.75 × 10–13 2.69 × 10–4 9.97 × 10–3 1.36 × 10–2 P
cg04988978 − 7.29 × 10–2 − 1.15 × 10–2 5.28 × 10–3 3.59 × 10–4 − 1.19 × 10–3 − 1.88 × 10–3 − 2.88 × 10–3 − 3.54 × 10–3 Coefficient
5.15 × 10–2 2.64 × 10–3 1.20 × 10–3 4.08 × 10–4 1.92 × 10–4 4.15 × 10–4 9.02 × 10–4 1.67 × 10–3 SE*
1.57 × 10–1 1.26 × 10–5 1.08 × 10–5 3.80 × 10–1 5.79 × 10–10 5.97 × 10–6 1.41 × 10–3 3.47 × 10–2 P
  1. *BMI, Body mass index; HDL-C, Cholesterol in high-density lipoprotein; LDL-C, Cholesterol in low-density lipoprotein; TG, Triglycerides; SBP, Systolic blood pressure; DBP, Diastolic blood pressure; SE, Standard Error