Table 5 Associations between the identified CpGs and classical cardiovascular risk factors (CVRFs) in the fixed-effects meta-analyses of the four samples
From: DNA methylation biomarkers of myocardial infarction and cardiovascular disease
CpG | Smoking | BMI* | HDL-C* | LDL-C* | TG* | Glucose | SBP | DBP* | |
|---|---|---|---|---|---|---|---|---|---|
cg21566642 | − 1.61 | 9.55 × 10–3 | 7.69 × 10–4 | − 1.10 × 10–3 | − 4.17 × 10–4 | 2.32 × 10–4 | 2.30 × 10–3 | 7.97 × 10–3 | Coefficient |
4.22 × 10–2 | 2.65 × 10–3 | 1.21 × 10–3 | 4.09 × 10–4 | 1.95 × 10–4 | 4.20 × 10–4 | 9.02 × 10–4 | 1.67 × 10–3 | SE* | |
< 2.2 × 10–16 | 3.21 × 10–4 | 5.24 × 10–1 | 7.11 × 10–3 | 3.22 × 10–2 | 5.81 × 10–1 | 1.08 × 10–2 | 1.78 × 10–6 | P | |
cg05575921 | − 1.61 | 1.17 × 10–2 | 4.36 × 10–3 | − 1.35 × 10–3 | − 7.09 × 10–4 | 1.86 × 10–4 | 2.15 × 10–3 | 7.54 × 10–3 | Coefficient |
4.22 × 10–2 | 2.46 × 10–3 | 1.11 × 10–3 | 3.77 × 10–4 | 1.79 × 10–4 | 3.87 × 10–4 | 8.23 × 10–4 | 1.52 × 10–3 | SE* | |
< 2.2 × 10–16 | 2.22 × 10–6 | 8.22 × 10–5 | 3.39 × 10–4 | 7.63 × 10–5 | 6.30 × 10–1 | 9.06 × 10–3 | 7.69 × 10–7 | P | |
cg25769469 | − 9.01 × 10–2 | − 1.12 × 10–2 | 6.76 × 10–3 | 2.47 × 10–4 | − 1.38 × 10–3 | − 1.52 × 10–3 | − 2.35 × 10–3 | − 4.17 × 10–3 | Coefficient |
5.08 × 10–2 | 2.64 × 10–3 | 1.20 × 10–3 | 4.11 × 10–4 | 1.93 × 10–4 | 4.17 × 10–4 | 9.10 × 10–4 | 1.69 × 10–3 | SE* | |
7.65 × 10–2 | 2.32 × 10–5 | 1.92 × 10–8 | 5.48 × 10–1 | 8.75 × 10–13 | 2.69 × 10–4 | 9.97 × 10–3 | 1.36 × 10–2 | P | |
cg04988978 | − 7.29 × 10–2 | − 1.15 × 10–2 | 5.28 × 10–3 | 3.59 × 10–4 | − 1.19 × 10–3 | − 1.88 × 10–3 | − 2.88 × 10–3 | − 3.54 × 10–3 | Coefficient |
5.15 × 10–2 | 2.64 × 10–3 | 1.20 × 10–3 | 4.08 × 10–4 | 1.92 × 10–4 | 4.15 × 10–4 | 9.02 × 10–4 | 1.67 × 10–3 | SE* | |
1.57 × 10–1 | 1.26 × 10–5 | 1.08 × 10–5 | 3.80 × 10–1 | 5.79 × 10–10 | 5.97 × 10–6 | 1.41 × 10–3 | 3.47 × 10–2 | P |