Fig. 4

ZBTB18 expression in primary colorectal tumors. Normal colonic epithelial cells had high expression of ZBTB18 (a–b). Significant variability was observed in the expression of ZBTB18 in colorectal tumors (c–g). i Histogram showing the average (± SEM) expression of ZBTB18 in normal colonic epithelial cells, primary colorectal tumors and lymph node metastases. j ZBTB18 expression in 13 primary colorectal tumors and paired lymph node metastasis. k–l Overall (k) and disease-free (l) survival as a function of ZBTB18 expression in the tumors from 132 Dukes’ C colorectal cancer patients is shown. N: number of samples. Scale bar: 50 µm. Student’s t test *p < 0.05 and ***p < 0.0001