Table 4 Human canonical core histones of the H4 family with their chromosomal location, expression and function
From: The dark side of histones: genomic organization and role of oncohistones in cancer
Gene name* | Histone protein codified | Gene chromosomal location | Expression | Function | References | |
|---|---|---|---|---|---|---|
Canonical H4 core histones | ||||||
1 | HIST1H4A | H4 | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
2 | HIST1H4B | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
3 | HIST1H4C | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
4 | HIST1H4D | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
5 | HIST1H4E | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
6 | HIST1H4F | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
7 | HIST1H4H | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
8 | HIST1H4I | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
9 | HIST1H4J | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
10 | HIST1H4K | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
11 | HIST1H4L | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
12 | HIST2H4A | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] | |
13 | HIST2H4B | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] | |
14 | HIST4H4 | 12p12.3 (in histone cluster 4) | Replication-dependent | Core component of nucleosome | [18] | |
15 | HIST1H4G | H4-like protein type G | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |