From: The dark side of histones: genomic organization and role of oncohistones in cancer
Gene name* | Histone protein codified | Gene chromosomal location | Expression | Function | References | |
---|---|---|---|---|---|---|
Canonical H3 core histones | ||||||
1 | HIST1H3A | H3.1 | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] |
2 | HIST1H3B | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
3 | HIST1H3C | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
4 | HIST1H3D | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
5 | HIST1H3E | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
6 | HIST1H3F | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
7 | HIST1H3G | 6p22.2 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
8 | HIST1H3H | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
9 | HIST1H3I | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
10 | HIST1H3J | 6p22.1 (in histone cluster 1) | Replication-dependent | Core component of nucleosome | [18] | |
11 | HIST2H3A | H3.2 | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] |
12 | HIST2H3C | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] | |
13 | HIST2H3D | 1q21.2 (in histone cluster 2) | Replication-dependent | Core component of nucleosome | [18] | |
14 | HIST3H3 (or H3-4) | H3.1t (or H3.4)§ | 1q42.13 (in histone cluster 3) | Replication-dependent and tissue-specific (testis-specific) | Core component of nucleosome | |
Non-canonical H3 core histones | ||||||
1 | H3-3A and H3-3B | H3.3 | 1q42.12 and 17q25.1 | Replication-independent | Induction of gene activation and involvement in gene expression regulation | |
2 | CENPA | CENP-A | 2p23.3 | Replication-independent | Required for recruitment and assembly of kinetochore proteins and progression through mitosis, chromosome segregation and cytokinesis | |
3 | H3F3C (or H3-5) | H3.3C (or H3.5) | 12p11.21 | Replication-independent (specifically in seminiferous tubules of testis) | Colocalization with euchromatin and association with actively transcribed genes | [41] |
4 | H3Y2 | H3.X (or H3.Y2) | 5p15.1 | Replication-independent | Not yet clarified | [42] |
5 | H3Y1 | H3.Y (or H3.Y1) | 5p15.1 | Replication-independent | Involvement in the regulation of cellular responses to stress stimuli and regulation of transcription |