Table 6 Summary of the research works about SNP-CpG methylation interaction on specific genes in asthma
From: A review of epigenetic changes in asthma: methylation and acetylation
Author and year | Subjects | Specimen | Significant SNP/CpG | Gene | References |
|---|---|---|---|---|---|
Soto-RamÃrez et al. 2013 | 18-year-old females | Whole blood | rs3024685/ cg09791102 | IL4R | [13] |
Zhang et al. 2014 | Girls with the age of 10 and 18 | Whole and peripheral blood | rs3024685, rs8832/ cg26937798 (Related to IL4R) | IL4, IL4R, IL13, GATA3, and STAT6 | [62] |
Acevedo et al. 2015 | Boys and girls at age 8 | whole blood | rs7216389, rs4065275 and rs12603332 | GSDMB and ORMDL3 | [130] |
Mukherjee et al. 2016 | 18-year-old men and women and a subset of women at age 10 | Peripheral blood | rs11763517/cg00666422 | LEP | [128] |
Nicodemus-Johnson et al. 2016 | Adults | Endobronchial airway epithelial cells | rs2517955/cg05616858 | ORMDL3 | [131] |
Zhang et al. 2017 | Children with ages 5–8 | Nasal epithelial cells | 6 significant interaction sites out of 182 SNPs | OTX2 and LDHC | [129] |
Dijk et al. 2018 | Children at age 4 | Whole blood | rs1420101/cg11916609, rs56179005/cg20060108,rs76886731/cg25869196,and rs1420104/cg19795292 | IL1RL1 | [127] |
Kim et al. 2019 | Puerto Rican and African-American children | Nasal epithelial cells | - | - | [124] |
Kogan et al. 2019 | Adults | Whole blood | rs10818651/cg21469772, rs10985567/cg21213617 | LOC101928523, SCARNA18, LHX6, and STC1 | [132] |