A review of epigenetic changes in asthma: methylation and acetylation

Clinical Epigenetics

Table 5 Summary of the research works about the role of epigenetics in determining the propensity for asthma later in life and in the next generations

Author and year	Subject	Gene/region	Epigenetic changes	Phenotype	References
DeVries et al. 2015	Children	SMAD3	Hypermethylation	Childhood asthma	[113]
Murphy et al. 2015	Monozygotic twins with asthma discordancy at age 10	HLX and HGSNAT	DNA methylation	Childhood asthma discordancy	[114]
Yue et al. 2017	Pregnant BALB/C mice	IL-4	Demethylation of the DNA	Allergic asthma in offsprings	[115]
Everson et al. 2019	Children up to 18	HK1	Hypomethylation	Adolescent asthma	[117]
Rehan et al. 2012	Pregnant Sprague Dawley F0 rats	PPARγ	DNA methylation and histone 3 and 4 acetylation in the lung and gonad	Childhood asthma predisposition in the F2 generation	[118]
Gunawardhana et al. 2014	12-month-old infants	11 genes including MAPK8IP3, AURKA, and PM20D1	DNA methylation	Asthma development	[122]
Gregory et al. 2017	Pregnant BALB/C mice	41 loci	DNA methylation	Asthma susceptibility in the F2 and F3 generations	[119]
Den Dekker et al. 2019	Children	18 asthma-related differentially methylated regions	DNA methylation	Childhood asthma	[116]

ISSN: 1868-7083