A review of epigenetic changes in asthma: methylation and acetylation

Sheikhpour, Mojgan; Maleki, Mobina; Ebrahimi Vargoorani, Maryam; Amiri, Vahid

doi:10.1186/s13148-021-01049-x

Clinical Epigenetics

Table 4 Summary of studies on transgenerational effects of epigenetic regulations in asthma

From: A review of epigenetic changes in asthma: methylation and acetylation

Author and year	Subjects	Gene/region	Epigenetic change	Environment	Phenotype	References
Perera et al. 2009	Dominican and African-American women and their children	ACSL3	CpG methylation	Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons	Childhood asthma	[80]
Brand et al. 2011	BALB/c mice and BALB/cscid mice	IFN-γ, IL-4, IL-5, and CNS1	histone H4 acetylation	Microbiome	Transmaternal asthma protection	[107]
Torrone et al. 2012	Inner-city children	IFN-γ and iNOS	DNA methylation	-	Asthma	[99]
Fu et al. 2012	Children	ADRB2	Hypermethylation	NO2 exposure	Childhood asthma severity	[93]
Reinius et al. 2013	Children and adults	NPSR1	DNA methylation	Current smoking in adults and parental smoking in children	Adult severe asthma and childhood allergic asthma	[53]
Kuo et al. 2013	Adults	IRF7	Histone H3Lys4 trimethylation	Exposure to Diethylhexyl phthalate and butyl benzyl phthalate	Asthma development	[88]
Michel et al. 2013	Children	ORMDL1, ORMDL2, ORMDL3, CHI3L1, RAD50, IL13, IL4, STAT6, FOXP3, and RUNX3	DNA methylation	Farm exposure in early childhood	Asthma protection	[108]
Sofer et al. 2013	Male adults	Genes like, HLA-DOB, FCER1A, FCER1G, MBP, HLA-DPA1, IL-9, IL-10, ECP, and CCL11	DNA methylation	Exposures to black carbon and sulfate	Asthma	[84]
Gaffin et al. 2014	Inner-city children	ADRB2	DNA methylation	-	Decreased asthma severity	[92]
Wang et al. 2015	Children	AR, TNF-α, and IL-4	DNA methylation	Phthalate exposure	Childhood asthma	[89]
Yang et al. 2015	inner-city children	IL13, RUNX3, ST2, and IL4	Hypomethylation and hypermethylation	-	persistent childhood atopic asthma	[91]
Sarnowski et al. 2016	Families with different nationalities	MTNR1A	DNA methylation	-	Co-occurrence of asthma and rhinitis	[79]
Somineni et al. 2016	Children (siblings) with age 5–18	TET1	DNA methylation	Exposure traffic-related air pollution	Childhood asthma	[87]
Jung et al. 2017	Children	IL-4, IFN-γ, NOS2A, and ARG2	DNA methylation	Short-term exposure to PM2.5 and vanadium	Childhood asthma	[81]
Chan et al. 2017	Children	-	Higher global DNA methylation	Socioeconomic status and race/ethnicity	Childhood asthma	[95]
Montrose et al. 2017	Children	IFN-γ	DNA methylation	Dietary intake	Childhood asthma	[98]
Wang et al. 2017	Children	IL4	Increased DNA methylation	Dust mite allergen-specific immunotherapy	Childhood allergic asthma	[110]
Christensen et al. 2017	C57BL6 mice	IL-4, IL-5, IL-13, IFN-γ, and FOXP3	DNA methylation	Prenatal tobacco smoke exposure	Susceptibility to asthma	[75]
Jung et al. 2017	Children	IL-4 and NOS2A	Demethylation of DNA	Exposure to black carbon	Allergic asthma	[85]
Pech et al. 2018	Children	BAT3, NEU1, and 14 other CpGs	DNA methylation	Rhinovirus infection	Childhood asthma	[100]
Gao et al. 2018	Newborns and children	AXL	Hypermethylation	prenatal tobacco smoke exposure	Childhood asthma	[76]
Zhang et al. 2018	Children (siblings) with age 5–18	NLRP3, OR2B11, and TET1	DNA methylation	Traffic-related air pollution and house dust mite	Childhood asthma	[86]
Prunicki et al. 2018	Children	Foxp3 and IL-10	DNA methylation	Exposure to NO2, CO, and PM2.5	Childhood asthma	[82]
Zhou et al. 2019	BALB/c mice	IL-4	Hyperacetylation of H3Lys9 and H3Lys14	Exposure to PM2.5 and cold stress	Asthma exacerbation	[83]
Neophytou et al. 2019	Children	AHRR	DNA methylation	Maternal smoking during pregnancy	Asthma development	[77]
Wu et al. 2019	Children and newborns	LMO2, GSTM1, and IL-10	Hypermethylation	Prenatal exposure to paternal tobacco smoke	Childhood asthma at age 6	[78]
Chen et al. 2019	C57BL/6 J mice	Th2 cytokine locus	Hypomethylation	Early-life undernutrition	Susceptibility to asthma	[97]
Kyburz et al. 2019	C57BL/6 mice	CXCR3 and FOXP3	DNA methylation	Transmaternal Helicobacter pylori exposure	Asthma protection	[109]
Qi et al. 2020	Children	60 CpG regions associated with asthma/rhinitis	CpG methylation	active and passive smoking, molds, and pets	Asthma, rhinitis, asthma/rhinitis at age 16	[96]
Nafea et al. 2020	Children	ADRB2	Hypermethylation	Blood aluminum concentration	Bronchial asthma	[94]
Yang et al. 2020	Children	MAPK1	Hypomethylation	Bisphenol A exposure	Asthma	[90]

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