A review of epigenetic changes in asthma: methylation and acetylation

Clinical Epigenetics

Table 3 Summary of the studies on the impact of the subject's characteristics on the methylation status in asthma

Author and references	Year	Subject	Characteristics	Specimen	Genes/regions
Sood et al. [65]	2012	Old male adults	Age	Sputum	PAX5-α and PCDH20
Naumova et al. [52]	2013	Male and female adults and children	Sex and age	PBMC	ZPBP2 and 17q12-q21 region
Reinius et al. [53]	2013	Children and adults	Age	Peripheral blood	NPSR1
Rastogi et al. [68]	2013	Children	Disorder: obesity	PBMC	CCL5,IL2RA,TBX21,FCER2,TGFB1, Th1 polarization-associated genes, IgE low-affinity receptor gene, and Th cell activation inhibitor gene
Curtin et al. [61]	2013	Children with ages 2 and 8	Age	Cord blood	IL-2
Lovinsky-Desir et al. [56]	2014	Adult and children	Age	Buccal cells and PBMC	IFN-γ
Zhang et al. [62]	2014	Girls with the age of 10 and 18	Age	Whole and peripheral blood	IL4, IL4R, IL13, GATA3, and STAT6
Guthikonda et al. [64]	2014	18-year-old females	Drug: OCP	Peripheral blood	GATA3
Tuwaijri et al. [54]	2016	Male and female adults	Sex	Peripheral blood	17q12–q21 and 5q31.1 regions
Janjanam et al. [63]	2016	10- and 18-year-old females	Vaccination	Guthrie cards and whole blood	KIAA1549L, PSMG3, and TFAMP1
Gao et al. [55]	2017	Children	Sex	Bloodspots	AXL
Peng et al. [60]	2019	Children	Age	Peripheral and cord blood	-
Jeong et al. [69]	2019	Female adults	BMI status	Peripheral blood	Inflammatory pathway and NLRP3-IL1B-IL17 axis-related genes
Wu et al. [70]	2019	APP/PS1 and C57BL/6 J mice	Disorder: Alzheimer's disease	BALF cells	Foxp3

ISSN: 1868-7083