A review of epigenetic changes in asthma: methylation and acetylation

Clinical Epigenetics

Table 2 Summary of the research works about the role of histone acetylation and its regulatory enzymes in asthma-related genes and pathways

Author and year	Subjects	Specimen	Gene	Highlighted epigenetic effect	References
Li et al. 2010	Adults	Cultured human A549 alveolar epithelial cells, PBMC and BALF RNA samples	HDAC2	HDAC2 is regulated by GRβ resulting in the downregulation of HDAC2	[47]
Mishra et al. 2011	Ovalbumin sensitized and challenged mice and saline sensitized and challenged mice	Lung tissue	Socs3	Histone H4 acetylation and DNA methylation	[40]
Butler et al. 2012	Adults	Primary bronchial epithelial cell culture	HDAC2 and HDAC1	In severe asthma, no change in HDAC2 and HDAC1 expression caused by GRβ was observed	[48]
Li et al. 2013	Human adults and Wistar rats	Human peripheral blood T-cells and rat lung T-cells	LAT	H3 and H4 acetylation and H3 Lys9 dimethylation	[37]
Gunawardhana et al. 2014	Adults	Peripheral blood monocytes and sputum macrophages	-	The interplay between HAT and HDAC affects airway inflammation in asthma	[49]
Seumois et al. 2014	Adults	Peripheral blood and primary human CD4 + T-cells	T-cell enhancers	H3 Lys4 dimethylation	[38]
Clifford et al. 2015	Adults	Primary cultures of human ASM (HASM) cells isolated from bronchial biopsies and large airway tissue	CXCL8	H3Lys18 acetylation	[44]
Wawrzyniak et al. 2016	Adults	Air liquid interface cultures of human primary bronchial epithelial cells in	Tight junctions	Histone acetylation	[35]
Stadhouders et al. 2018	Gata3YFP/YFP reporter mice	ILC2s and human peripheral blood	ILC2 genes	H3 lys4 dimethylation	[51]
Cheng et al. 2019	Female BALB/c mice	Lung tissue	ORMDL3	Histone acetylation	[46]

ISSN: 1868-7083