Table 5 Network medicine approach in cancer and CVDs

FEM

Endometrial tumor samples and 23 healthy controls

DNA methylation of HAND2 gene in 90% of tumors

Jiao et al. [67], Jones et al. [69]

OxyBS

Fresh frozen glioblastoma specimens from 30 subjects diagnosed between 2004 and 2012

5-Hydroxymethylcytosine patterns are strongly related to transcription, localizes to disease-critical genes and are associated with patient prognosis

Johnson et al. [68]

WGBS + WGS

Biopsy 100 castration-resistant prostate metastases

Discovery of association between hypermethylation and somatic mutations in TET2, DNMT3B, IDH1 and BRAF in epigenomic subtype

Zhao et al. [142]

WGCNA

Blood samples isolated from 2627 subjects enrolled in FHS cohort

Differences in circulating DNA methylation signatures located in regulatory regions of SLC9A1, SLC1A5, TNRC6C genes may be useful biomarkers to predict incident CHD

Westerman et al. [137]