Fig. 2

Gene set enrichment analysis showing the correlation of the gene set, which are established in extracellular matrix organization (a), cardiac muscle contraction (b), and fatty acid metabolism (c), in annotated genes from differentially acetylated regions (histone acetylome), differentially expressed genes (transcriptome), and genes encoding differentially expressed proteins (proteome), respectively. Differentially expressed genes were ranked by their fold changes and shown on the x-axis. The running correlation throughout the gene set is shown by the curve (green), and the running enrichment score (ES) is shown on the y-axis. Enrichment score normalized for gene set size (NES), familywise-error rate P value (FWER), and the false discovery rate (FDR) are shown per enrichment plot