Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence

Clinical Epigenetics

Table 2 Effects of DNAm on BMI status transition (irrespective to gender) during adolescence

Name	10–18 years (IoW)			7–15 years (ALSPAC)
Name	Est.*	p_raw*	P_FDR*	Est	p_raw	Gene name	Gene’s location
Transition from Normal to OwO*
cg14062083	6.49	1.29 × 10^–4	0.01	–	–	KRTAP13-4	1stExon
cg17866181	−2.94	2.76 × 10^–4	0.01	−0.05	0.76	*BC036251*	*Body*
Transition from OwO to Normal
cg02906784	4.95	2.33 × 10^–4	0.02	−0.56	0.31	CACNA2D3	Body
cg07728579	5.00	3.38 × 10^–4	0.02	−0.33	0.50	FSD2	TSS500
cg18935453	5.08	5.79 × 10^–4	0.02	–	–	LRP5	Body
cg23664926	2.76	7.16 × 10^–4	0.02	−0.11	0.72	CD82^#	–
cg10320997	3.83	9.97 × 10^–4	0.02	−0.17	0.67	SYNPO2	TSS1500
cg02382044	2.30	0.002	0.04	−0.44	0.20	TMOD3	TSS1500
cg16460342	−3.63	0.002	0.04	−0.65	0.07	*P2RX4*	Body

In total, 9 CpG sites were identified in the IoW cohort, which were further tested in the ALSPAC cohort. Results in bold font denote that the estimated regression coefficients are in the same direction between the two cohorts
^*OwO means Overweight/Obese. Est.: Estimate of regression coefficients. p_raw: raw p value. p_FDR: FDR-adjusted p value. # Gene CD82 was identified using SNIPPER

ISSN: 1868-7083