Skip to main content
Fig. 6 | Clinical Epigenetics

Fig. 6

From: Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases

Fig. 6

Genetic and environmental effects on methylation of CHRNA5 in relation to the risk of lung disease. The possible mechanism of methylation of CHRNA5 affecting the risk of lung disease is through both genetic control and environment influence. The MR test inferred the causal role of methylation of CHRNA5 on lung cancer and COPD. In another bidirectional MR test, the methylation of CHRNA5 and pack-years of smoking played causal roles with each other

Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us