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Table 5 Incident CVD hazard ratios for GrimAA and clinical CVD risk scores in GENOA African Americans

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Predictor Adjusted HR (95% CI)
FRS only (N = 945) ASCVD only (N = 988) FRS + GrimAA (N = 945) ASCVD + GrimAA (N = 988)
FRS 1.03 (1.02–1.05) P = 9.5 × 10–6 1.03 (1.01–1.05) P = 4.7 × 10–4
ASCVD 1.04 (1.02–1.06) P = 2.7 × 10–5 1.03 (1.01–1.05) P = 9.8 × 10–4
GrimAA 1.07 (1.02–1.13) P = 0.011 1.08 (1.02–1.13) P = 0.007
  1. Models consisted of clinical risk scores with and without GrimAA. All models were adjusted for age, sex, and familial relatedness
  2. Adjusted hazard ratios correspond to the risk of a CVD event associated with a 1-unit increase in the clinical risk score or the epigenetic age acceleration measure
  3. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  4. CVD, cardiovascular disease; HR, hazard ratio; FRS, Framingham risk score; ASCVD, atherosclerotic cardiovascular disease