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Table 3 Association between epigenetic age acceleration and clinical CVD risk scores in GENOA African Americans

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Epigenetic age acceleration (Predictor)

Framingham risk score (FRS) (N = 945)

Atherosclerotic cardiovascular disease equation (ASCVD) (N = 988)

β (95% CI)

P value

β (95% CI)

P value

IEAA

0.12 (− 0.02–0.26)

0.088

0.17 (0.06–0.29)

0.004

EEAA

0.21 (0.10–0.32)

3.77 × 10–4

0.23 (0.13–0.33)

3.85 × 10–6

PhenoAA

0.15 (0.06–0.24)

0.001

0.18 (0.10–0.26)

4.78 × 10–6

GrimAA

0.58 (0.44–0.71)

4.53 × 10–16

0.44 (0.33–0.56)

2.38 × 10–13

  1. Models are adjusted for age, sex, and familial relatedness
  2. IEAA, Intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration
  3. FRS and ASCVD are modeled as continuous predictors
  4. Effect sizes (β) correspond to the change in predicted 10-year risk of CVD using the FRS or ASCVD risk equation associated with 1-year increase in the epigenetic age acceleration measure
  5. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  6. Associations significant at P < 0.05 are shown in bold
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Clinical Epigenetics

ISSN: 1868-7083

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