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Table 3 Association between epigenetic age acceleration and clinical CVD risk scores in GENOA African Americans

From: Epigenetic age acceleration is associated with cardiometabolic risk factors and clinical cardiovascular disease risk scores in African Americans

Epigenetic age acceleration (Predictor) Framingham risk score (FRS) (N = 945) Atherosclerotic cardiovascular disease equation (ASCVD) (N = 988)
β (95% CI) P value β (95% CI) P value
IEAA 0.12 (− 0.02–0.26) 0.088 0.17 (0.06–0.29) 0.004
EEAA 0.21 (0.10–0.32) 3.77 × 10–4 0.23 (0.13–0.33) 3.85 × 10–6
PhenoAA 0.15 (0.06–0.24) 0.001 0.18 (0.10–0.26) 4.78 × 10–6
GrimAA 0.58 (0.44–0.71) 4.53 × 10–16 0.44 (0.33–0.56) 2.38 × 10–13
  1. Models are adjusted for age, sex, and familial relatedness
  2. IEAA, Intrinsic epigenetic age acceleration; EEAA, extrinsic epigenetic age acceleration
  3. FRS and ASCVD are modeled as continuous predictors
  4. Effect sizes (β) correspond to the change in predicted 10-year risk of CVD using the FRS or ASCVD risk equation associated with 1-year increase in the epigenetic age acceleration measure
  5. Cardiovascular disease (CVD) was defined as self-reported myocardial infarction, coronary artery revascularization, cerebrovascular events, or surgical carotid artery revascularization
  6. Associations significant at P < 0.05 are shown in bold