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Table 1 Change between pre- and post-measurements

From: Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity

  Baseline Week 12 Difference p value
Age years, mean ± SD 73.50 ± 5.72    
Sex
 Female 14 (87.5%)    
 Male 2 (12.5%)    
Body Measures, mean ± SD
 Weight (kg) 95.7 ± 21.3 91.5 ± 22.1 − 4.2 ± 3.7  < 0.001
 Body Mass Index (kg/m2) 36.2 ± 7.0 34.6 ± 7.4 − 1.6 ± 1.4  < 0.001
 Fat Mass (%) 49.0 ± 5.0 48.0 ± 5.5 − 0.9 ± 2.4 0.13
 Visceral Fat mass, (L) 4.0 ± 1.8 3.6 ± 2.2 − 0.4 ± 1.0 0.15
 Skeletal muscle mass (kg) 48.8 ± 15.9 47.5 ± 15.0 − 1.3 ± 2.3 0.04
 Appendicular lean mass (kg) 12.3 ± 4.0 12.1 ± 3.8 − 0.3 ± 0.7 0.11
Functional measures, mean ± SD
 Grip strength (kg) 18.7 ± 5.9 21.9 ± 6.6 3.2 ± 4.1 0.008
 Gait speed (sec) 1.1 ± 0.3 1.1 ± 0.25 0.02 ± 0.2 0.69
 Sit-to-stand (sec) 10.0 ± 2.7 7.6 ± 1.8 − 2.4 ± 2.2  < 0.001
 Six-minute walk (m) 406.4 ± 101.1 448.6 ± 82.12 29.3 ± 34.6 0.006
Immune Cell Proportions, mean ± SD
 CD8T 0.06 ± 0.02 0.06 ± 0.02 0.00 ± 0.01 0.16
 CD4T 0.18 ± 0.03 0.18 ± 0.03 − 0.00 ± 0.02 0.81
 Natural Killer Cells 0.05 ± 0.02 0.05 ± 0.02 0.00 ± 0.01 0.4
 B Cells 0.05 ± 0.02 0.05 ± 0.02 − 0.00 ± 0.01 0.76
 Monocyte 0.08 ± 0.02 0.07 ± 0.02 − 0.00 ± 0.01 0.06
 Neutrophils 0.62 ± 0.05 0.62 ± 0.05 − 0.00 ± 0.03 0.97
Methylation age clocks, mean ± SD
 Hannum 79.4 ± 6.8 78.6 ± 6.6 − 0.8 ± 4.8 0.51
 Horvath 79.3 ± 6.8 78.2 ± 6.4 − 1.1 ± 2.8 0.14
 PhenoAge 62.7 ± 6.4 62.3 ± 7.0 − 0.5 ± 4.1 0.64