DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

Clinical Epigenetics

Table 3 Predictive ability of DNA methylation for lymphatic–hematopoietic, solid and overall cancers in the Strong Heart Study from the elastic-net model

	N predictors	Lymphatic–hematopoietic cancer		Solid cancers		Overall cancer
	N predictors	C index	N coef > 0^b	C index	N coef > 0^b	C index	N coef > 0^b
Risk factors^a	5	0.50	0	0.66	5	0.65	5
Risk factors^a + cell counts + genetic PCs	15	0.50	0	0.67	15	0.66	14
Risk factors^a + cell counts + genetic PCs + DMPs	788,383	0.87	126	0.79	396	0.79	414

coef coefficient, PCs principal components, DMPs Differentially Methylated Positions
^aAge (years), smoking status (current/former/never), sex (men/women), BMI (kg/m²) and study center (AZ, OK, ND/SD)
^bVariables with coef 0 are considered not to play any role in prediction

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