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Table 3 Predictive ability of DNA methylation for lymphatic–hematopoietic, solid and overall cancers in the Strong Heart Study from the elastic-net model

From: DNA methylation and cancer incidence: lymphatic–hematopoietic versus solid cancers in the Strong Heart Study

  N predictors Lymphatic–hematopoietic cancer Solid cancers Overall cancer
  C index N coef > 0b C index N coef > 0b C index N coef > 0b
Risk factorsa 5 0.50 0 0.66 5 0.65 5
Risk factorsa + cell counts + genetic PCs 15 0.50 0 0.67 15 0.66 14
Risk factorsa + cell counts + genetic PCs + DMPs 788,383 0.87 126 0.79 396 0.79 414
  1. coef coefficient, PCs principal components, DMPs Differentially Methylated Positions
  2. aAge (years), smoking status (current/former/never), sex (men/women), BMI (kg/m2) and study center (AZ, OK, ND/SD)
  3. bVariables with coef 0 are considered not to play any role in prediction