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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts

Fig. 3

Overlap of a cis-meQTL for cg06500161 (ABCG1, SNP rs220182) and a trans-meQTL for cg19693031 (TXNIP, SNP rs6657798), with a a GWAS SNP for HOMA-B and b a GWAS SNP for 2-h glucose, respectively. meQTL were retrieved from the Genetics of DNAm consortium (GoDMC, www.godmc.org.uk/) [29] at p < 10–8 for cis-meQTL (SNPs within 1 Mb from CpG position) and at p < 10–14 for trans-meQTL (SNPs > 1 Mb or in different chromosomes from CpG position). GWAS SNPs for the glycemic traits were retrieved from the MAGIC consortium (https://www.magicinvestigators.org/) [30, 31]. Associations of peripheral blood DNAm with HOMA-B and 2-h glucose were estimated using linear regressions adjusted for age and sex, when appropriate, in two subsamples of diabetes-free individuals in ALSPAC (n = 622 for HOMA-B (only females) and n = 1002 for 2-h glucose)

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Clinical Epigenetics

ISSN: 1868-7083

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