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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer

Fig. 2

Differential DNA methylation analysis to separate tumor entities. a After performing an ANOVA (FDR < 1 × 10–6, σ/σmax > 0.25) a hierarchical cluster analysis of the 300 resulting loci separated SCLC and NSCLC specimens in biopsy samples. Boxes on top of the heatmap: yellow boxes: SCLC, red boxes: AC, blue boxes: SQC. Methylation values are presented without further normalization (avg.beta values). b Furthermore, a t-test statistic (FDR < 0.05, σ/σmax > 0.55) separating AC and SQC in biopsy specimens with certain diagnosis resulted in 15 loci. This set of loci separates both entities in the biopsy cohort in a subsequent hierarchical cluster analysis. Boxes on top of the heatmap: red boxes: AC, blue boxes: SQC. For presentation, mean methylation of each locus was normalized to zero (mean = 0). Heatmap: blue: low, yellow: high DNA methylation

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