Table 1 SMYD3 Histone and Non-Histone Substrates
From: SMYD3: a regulator of epigenetic and signaling pathways in cancer
Substrate | Enzyme endproduct | References |
|---|---|---|
Histone substrates | ||
H3K4 | Di- and Tri-methylation of H3K4 | [23] |
H4K5 | Mono-methylation (to the greatest degree), di-methylation, and tri-methylation of H4K5 | [24] |
H4K20 | Tri-methylation of H4K20 | [10] |
Non-histone substrates | ||
VEGFR1 (vascular endothelial growth factor receptor 1) | Methylation of VEGFR1 at lysine 831 | [26] |
MAP3K2 (MAP 3 Kinase 2) | Mono-, di-, or tri-methylation of MAP3K2 at lysine 260 | [27] |
AKT1 | Methylation of AKT1 at lysine 14 | [28] |
ER (estrogen receptor) | Transcriptional coactivator of ER | [29] |
HER2 (human epidermal growth factor receptor 2) | Tri-methylation of HER2 at lysine 175 | [30] |