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Fig. 2 | Clinical Epigenetics

Fig. 2

From: 5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells

Fig. 2

Glycosylation changes are cell line specific. a Representative UPLC chromatograms produced from secreted N-glycans of ovarian (A2780, A2780cis, PEO1 and PEO4) and triple negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-436) and their separation into 35 peaks. b Plotted peak areas from the secreted N-glycans of ovarian and breast cancer cell lines. The glycans in each peak (GP1–GP35) and features are listed in Additional file 2: Table S1. Significant changes (p  < 0.05) are starred: *P value ≤ 0.05 or **p value ≤ 0.005. (MANOVA). Heatmap histograms indicating fold changes in 5-AZA-dC treated compared to untreated cells, were created using Hierarchial Clustering Explorer HCE 3.5 software. Blue indicates decreases, and red indicates increases. The shade of colour corresponds to amounts of the decreases/increases

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