|
Variables
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
Odds ratio (95% CI)
|
P value
|
Odds ratio (95% CI)
|
P value
|
|---|
|
LEP methylation
|
0.452 (0.208–0.982)
|
0.045
|
0.330 (0.135–0.806)
|
0.015
|
|
Age
|
0.215 (0.091–0.509)
|
0.000
|
0.191 (0.076–0.479)
|
0.000
|
|
WBC
|
0.349 (0.157–0.778)
|
0.010
|
0.522 (0.215–1.266)
|
0.151
|
|
Cytogenetic risks
|
0.463 (0.239–0.899)
|
0.023
|
0.398 (0.189–0.838)
|
0.015
|
|
NPM1 mutations
|
2.005 (0.620–6.488)
|
0.246
| | |
|
FLT3-ITD mutations
|
0.764 (0.180–3.251)
|
0.715
| | |
|
C-KIT mutations
|
2.458 (0.392–15.426)
|
0.337
| | |
|
N/K-RAS mutations
|
0.481 (0.122–1.902)
|
0.297
| | |
|
DNMT3A mutations
|
0.605 (0.112–3.286)
|
0.561
| | |
|
U2AF1 mutations
|
Undermined
|
0.999
| | |
|
IDH1/2 mutations
|
1.045 (0.167–6.555)
|
0.962
| | |
|
SRSF2 mutations
|
Undermined
|
0.999
| | |
|
SETBP1 mutations
|
1.579 (0.096–26.002)
|
0.749
| | |
- Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109 /L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis
