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Table 3 Logistic regression analyses of variables for complete remission in non-M3 AML patients

From: Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

Variables

Univariate analysis

Multivariate analysis

Odds ratio (95% CI)

P value

Odds ratio (95% CI)

P value

LEP methylation

0.452 (0.208–0.982)

0.045

0.330 (0.135–0.806)

0.015

Age

0.215 (0.091–0.509)

0.000

0.191 (0.076–0.479)

0.000

WBC

0.349 (0.157–0.778)

0.010

0.522 (0.215–1.266)

0.151

Cytogenetic risks

0.463 (0.239–0.899)

0.023

0.398 (0.189–0.838)

0.015

NPM1 mutations

2.005 (0.620–6.488)

0.246

  

FLT3-ITD mutations

0.764 (0.180–3.251)

0.715

  

C-KIT mutations

2.458 (0.392–15.426)

0.337

  

N/K-RAS mutations

0.481 (0.122–1.902)

0.297

  

DNMT3A mutations

0.605 (0.112–3.286)

0.561

  

U2AF1 mutations

Undermined

0.999

  

IDH1/2 mutations

1.045 (0.167–6.555)

0.962

  

SRSF2 mutations

Undermined

0.999

  

SETBP1 mutations

1.579 (0.096–26.002)

0.749

  
  1. Variables including LEP methylation (hypermethylation vs. non-hypermethylation), age (≤ 60 vs. > 60 years), WBC (≥ 30 × 109 vs. < 30 × 109 /L), and gene mutations (mutant vs. wild-type). Multivariate analysis includes variables with P < 0.100 in univariate analysis
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Clinical Epigenetics

ISSN: 1868-7083

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