Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

Table 4 Annotation file of the significant CpG sites with high genetic control

CpG site	Gene (Name)	Gene (Group)	Position^a	CpG-SNP^b	Alleles^d	MAF^c of CpG-SNPs	CpG Island (Name)	Relation_to_Island
cg06952798	MGMT	Body	131,356,999	rs78877238	C/T	0.05(T)		OpenSea
cg27275103	MGMT	Body	131,477,739	rs77705384	C/T	0.14(T)		OpenSea
cg16255663	MGMT	Body	131,350,999	rs61859885	G/A	0.09(A)		OpenSea
cg09993319	MGMT	Body	131,529,435	rs7898151	G/A/T	0.47(G)		OpenSea
cg17686260	MGMT	Body	131,412,764					OpenSea
cg26201213	MGMT	Body	131,265,796				chr10:131,264,948–131,265,710	S_Shore

^aPosition is for reference genome build hg19/GRCh37
^bCpG-SNP corresponds to the SNPs present at the CpG interrogation
^cMAF represents minor allele frequency, frequency of the second most frequent allele in 1000 Genomes European population. MAF of CpG-SNPs was obtained from Ensembl for hg19 (http://grch37.ensembl.org/)
^dReference/Alternative alleles (Forward strand)

ISSN: 1868-7083