Fig. 4

Overloading mechanical stress increases BRD4 binding to the H3K27ac on the promoter region of 17 genes including Trem1. a Venn diagram depicting the number of increased enriched genes binding to BRD4 or H3K27ac after overloading stress. b The 17 overlapped genes which have increased binding of BRD4 and H3K27ac were listed in the heat map. c Gene tracks of ChIP-seq signal for BRD4 and H3K27ac at the Trem1 gene loci in control (top) and MF group (bottom). The y-axis shows the relative enrichment of the ChIP-seq signal. The x-axis depicts genomic position. Red arrow indicates the promoter region of Trem1