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Fig. 3 | Clinical Epigenetics

Fig. 3

From: BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response

Fig. 3

Overloading mechanical stress increases BRD4 occupancy on inflammation and stress-related genes promoter region. a Genome-wide distribution of BRD4 in condylar cartilage from control (Con) and mechanical force (MF) group. The numbers on the top represent total peak numbers. b Heat maps of BRD4 occupancy on the promoter region (TSS ± 5 kb), aligned by the degree of BRD4 signal intensity in condylar cartilage from control (Con) and mechanical force (MF) group. c ChIP-seq tag distribution of BRD4 surrounding the TSS (± 5 kb) of the whole genome in the condyles from Con and MF groups. d KEGG pathway analysis of increased BRD4-binding peaks in rat TMJ cartilage after overloading mechanical stress. The top ten most significant enrichment pathways and the related details were shown. e GO analysis of increased BRD4-binding peaks in rat TMJ cartilage after overloading mechanical stress. The top six most significant enrichment GO terms which are related to inflammation and the details were shown

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Clinical Epigenetics

ISSN: 1868-7083

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